Research workbench
AlphaFold monomer V2.0 prediction for DNA-directed RNA polymerase I subunit RPA2 (Q9H9Y6)
Analyse AlphaFold monomer V2.0 prediction for DNA-directed RNA polymerase I subunit… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- Accession
- Q9H9Y6
- Type
- protein
- Length
- 1,135 residues
- Chains
- 1
- Collection
- MolNFT v1 / AlphaFold
- Contract
- 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
- Owner
- 0xf87a97E0A4bB354D834857B14296240B167cbe70
- Molecule
- DNA-directed RNA polymerase I subunit RPA2
- UniProt
- Q9H9Y6
- Pockets
- 15 · best druggability 0.77
Structure
1 distinct chain · 30% helix, 25% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | DNA-directed RNA polymerase I subunit RPA2 | protein | 1135 | 30% helix, 25% strand | Q9H9Y6 |
Pockets
15 pockets found on a 1 Å grid, 6 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 821 | 0.77 | 0.81 | 87 | empty |
| 2 | 320 | 0.62 | 0.79 | 38 | empty |
| 3 | 84 | 0.61 | 0.89 | 21 | empty |
| 4 | 426 | 0.60 | 0.76 | 44 | empty |
| 5 | 192 | 0.60 | 0.82 | 29 | empty |
Compared structures
- 7OB9 · Cryo-EM structure of human RNA Polymerase I in elongation state · an experimental structure of the same protein · chain A against B, TM-score 0.98
- 7OB9 · Cryo-EM structure of human RNA polymerase I in elongation state · an experimental structure of the same protein · chain A against B, TM-score 0.98
- 7VBC · Back track state of human RNA Polymerase I Elongation Complex · an experimental structure of the same protein · chain A against B, TM-score 0.98
- 7VBB · Structure of the post state human RNA Polymerase I Elongation Complex · an experimental structure of the same protein · chain A against B, TM-score 0.97
- 7VBA · Structure of the pre state human RNA Polymerase I Elongation Complex · an experimental structure of the same protein · chain A against B, TM-score 0.97
- 7OBB · Cryo-EM structure of human RNA Polymerase I Open Complex · an experimental structure of the same protein · chain A against B, TM-score 0.97
- 7OBB · Cryo-EM structure of human RNA polymerase I open complex · an experimental structure of the same protein · chain A against B, TM-score 0.97
- 7OBA · Cryo-EM structure of human RNA Polymerase I in complex with RRN3 · an experimental structure of the same protein · chain A against B, TM-score 0.97
- 7OBA · Cryo-EM structure of human RNA polymerase I in complex with RRN3 · an experimental structure of the same protein · chain A against B, TM-score 0.97
- 8A43 · Human RNA polymerase I · an experimental structure of the same protein · chain A against B, TM-score 0.95
- 8A43 · Human RNA polymerase I · an experimental structure of the same protein · chain A against B, TM-score 0.95
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9H9Y6
- Elsewhere: UniProt Q9H9Y6 · AlphaFold DB Q9H9Y6
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