Research workbench

AlphaFold monomer V2.0 prediction for rho-associated protein kinase 2 (Q62868)

Analyse AlphaFold monomer V2.0 prediction for rho-associated protein kinase 2 (Q62868) in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

Accession: Q62868
Type: protein
Length: 1,388 residues
Chains: 1
Collection: MolNFT v1 / AlphaFold
Contract: 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
Owner: 0xdF2b063d4B94F3f46D117B1af99A846bD4a59284
Molecule: Rho-associated protein kinase 2
UniProt: Q62868
Pockets: 12 · best druggability 0.67

Structure

1 distinct chain · 61% helix, 9% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Rho-associated protein kinase 2	protein	1388	61% helix, 9% strand	Q62868

Pockets

12 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	374	0.67	0.80	49	empty
2	95	0.44	0.79	24	empty
3	124	0.42	0.76	25	empty
4	66	0.41	0.81	14	empty
5	122	0.41	0.76	16	empty

Compared structures

2ROV · The split PH domain of ROCK II · an experimental structure of the same protein · chain A against A, TM-score 0.08
2ROV · The split pH domain of rock II · an experimental structure of the same protein · chain A against A, TM-score 0.08
2ROW · The C1 domain of ROCK II · an experimental structure of the same protein · chain A against A, TM-score 0.05
2ROW · The C1 domain of rock II · an experimental structure of the same protein · chain A against A, TM-score 0.05

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q62868
Elsewhere: UniProt Q62868 · AlphaFold DB Q62868

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