MolNFT v1 · #50645 · protein

The split pH domain of rock II

2ROV · Rho-associated protein kinase 2: “The split pH domain of rock II”. Solution nmr, 1 pocket (best druggability 0.26). MolNFT v1 #50645 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 2ROV
Type: protein
Length: 117 residues
Chains: 1
Method: solution nmr
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Rho-associated protein kinase 2
EC: 2.7.11.1
UniProt: Q62868
Pockets: 1 · best druggability 0.26

Structure

solution nmr · 1 distinct chain · 21% helix, 32% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Rho-associated protein kinase 2 (EC 2.7.11.1)	protein	117	21% helix, 32% strand	Q62868

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	50	0.26	0.73	12	empty

Compared structures

2ROV · The split PH domain of ROCK II · the same entry in another collection · chain A against A, TM-score 1.00
Q62868 · AlphaFold monomer V2.0 prediction for rho-associated protein kinase 2 (Q62868) · a predicted model of the same protein · chain A against A, TM-score 0.88

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q62868
Elsewhere: RCSB PDB 2ROV · PDBe 2ROV · UniProt Q62868

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