Research workbench
AlphaFold monomer V2.0 prediction for E3 ubiquitin-protein ligase RNF8 (O76064)
Analyse AlphaFold monomer V2.0 prediction for E3 ubiquitin-protein ligase RNF8 (O76064) in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- Accession
- O76064
- Type
- protein
- Length
- 485 residues
- Chains
- 1
- Collection
- MolNFT v1 / AlphaFold
- Contract
- 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
- Owner
- 0xD0f9B7bFD62aab6d4A30D170A574DcF201F3f893
- Molecule
- E3 ubiquitin-protein ligase RNF8
- UniProt
- O76064
- Pockets
- 2 · best druggability 0.35
Structure
1 distinct chain · 43% helix, 13% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | E3 ubiquitin-protein ligase RNF8 | protein | 485 | 43% helix, 13% strand | O76064 |
Pockets
2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 94 | 0.35 | 0.74 | 16 | empty |
| 2 | 58 | 0.28 | 0.74 | 17 | empty |
Compared structures
- 4ORH · Crystal structure of RNF8 bound to the UBC13/MMS2 heterodimer · an experimental structure of the same protein · chain A against G, TM-score 0.28
- 4ORH · Crystal structure of RNF8 bound to the UBC13/MMS2 heterodimer · an experimental structure of the same protein · chain A against G, TM-score 0.28
- 4AYC · RNF8 RING domain structure · an experimental structure of the same protein · chain A against A, TM-score 0.27
- 4AYC · RNF8 ring domain structure · an experimental structure of the same protein · chain A against A, TM-score 0.27
- 2CSW · Solution structure of the FHA domain of human ubiquitin ligase protein RNF8 · an experimental structure of the same protein · chain A against A, TM-score 0.27
- 2CSW · Solution structure of the fha domain of human ubiquitin ligase protein RNF8 · an experimental structure of the same protein · chain A against A, TM-score 0.27
- 2PIE · Crystal structure of the FHA domain of RNF8 in complex with its optimal phosphopeptide · an experimental structure of the same protein · chain A against A, TM-score 0.27
- 2PIE · Crystal structure of the fha domain of RNF8 in complex with its optimal phosphopeptide · an experimental structure of the same protein · chain A against A, TM-score 0.27
- 4WHV · E3 ubiquitin-protein ligase RNF8 in complex with Ubiquitin-conjugating enzyme E2 N and… · an experimental structure of the same protein · chain A against C, TM-score 0.26
- 4WHV · E3 ubiquitin-protein ligase RNF8 in complex with ubiquitin-conjugating enzyme E2 N and… · an experimental structure of the same protein · chain A against C, TM-score 0.26
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O76064
- Elsewhere: UniProt O76064 · AlphaFold DB O76064
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