UniProt O76064
E3 ubiquitin-protein ligase RNF8 (O76064)
E3 ubiquitin-protein ligase RNF8 (UniProt O76064): 10 experimental structures and 1 predicted model on GenesisL1, 2 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- O76064
- Protein
- E3 ubiquitin-protein ligase RNF8
- Experimental structures
- 10
- Predicted models
- 1
- Pockets
- 2 · 0 records with a druggable one
Structures
11 records of O76064 in the MolNFT archive: 10 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2CSW | Solution structure of the FHA domain of human ubiquitin ligase protein RNF8 | solution nmr | A | — | — |
| 2CSW | Solution structure of the fha domain of human ubiquitin ligase protein RNF8 | solution nmr | A | — | — |
| 2PIE | Crystal structure of the FHA domain of RNF8 in complex with its optimal phosphopeptide | x-ray diffraction | A | — | — |
| 2PIE | Crystal structure of the fha domain of RNF8 in complex with its optimal phosphopeptide | x-ray diffraction | A | — | — |
| 4AYC | RNF8 RING domain structure | x-ray diffraction | A, B | — | — |
| 4AYC | RNF8 ring domain structure | x-ray diffraction | A, B | — | — |
| 4ORH | Crystal structure of RNF8 bound to the UBC13/MMS2 heterodimer | x-ray diffraction | C, G, H, K, L | — | — |
| 4ORH | Crystal structure of RNF8 bound to the UBC13/MMS2 heterodimer | x-ray diffraction | C, G, H, K, L | — | — |
| 4WHV | E3 ubiquitin-protein ligase RNF8 in complex with Ubiquitin-conjugating enzyme E2 N and… | x-ray diffraction | C, D, I, J | — | — |
| 4WHV | E3 ubiquitin-protein ligase RNF8 in complex with ubiquitin-conjugating enzyme E2 N and… | x-ray diffraction | C, D, I, J | — | — |
| O76064 | AlphaFold monomer V2.0 prediction for E3 ubiquitin-protein ligase RNF8 (O76064) | predicted | A | — | 2 (best 0.35) |
Experiment against prediction
- 2PIE chain A against the predicted model O76064: TM-score 0.97, RMSD 0.81 Å
- 2PIE chain A against the predicted model O76064: TM-score 0.97, RMSD 0.81 Å
- 4ORH chain C against the predicted model O76064: TM-score 0.96, RMSD 0.82 Å
- 4ORH chain C against the predicted model O76064: TM-score 0.96, RMSD 0.82 Å
- 4ORH chain G against the predicted model O76064: TM-score 0.96, RMSD 0.95 Å
- 4ORH chain G against the predicted model O76064: TM-score 0.96, RMSD 0.95 Å
- 4WHV chain I against the predicted model O76064: TM-score 0.93, RMSD 1.28 Å
- 4WHV chain I against the predicted model O76064: TM-score 0.93, RMSD 1.28 Å
- 4AYC chain A against the predicted model O76064: TM-score 0.91, RMSD 1.54 Å
- 4AYC chain A against the predicted model O76064: TM-score 0.91, RMSD 1.54 Å
Elsewhere
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