Research workbench
AlphaFold monomer V2.0 prediction for DNA repair protein CRB2 (P87074)
Analyse AlphaFold monomer V2.0 prediction for DNA repair protein CRB2 (P87074) in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- Accession
- P87074
- Type
- protein
- Length
- 778 residues
- Chains
- 1
- Collection
- MolNFT v1 / AlphaFold
- Contract
- 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
- Owner
- 0x3B8980aa24D16c478Ffda87D4df057cca6FC37da
- Molecule
- DNA repair protein CRB2
- UniProt
- P87074
- Pockets
- 6 · best druggability 0.66
Structure
1 distinct chain · 16% helix, 13% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | DNA repair protein CRB2 | protein | 778 | 16% helix, 13% strand | P87074 |
Pockets
6 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 308 | 0.66 | 0.81 | 35 | empty |
| 2 | 240 | 0.59 | 0.79 | 27 | empty |
| 3 | 347 | 0.59 | 0.76 | 49 | empty |
| 4 | 109 | 0.39 | 0.75 | 16 | empty |
| 5 | 72 | 0.37 | 0.77 | 18 | empty |
Modifications
Observed in the structure: 1 disulfide (disulfide).
Compared structures
- 2VXC · Structure of the Crb2-BRCT2 domain complex with phosphopeptide. · an experimental structure of the same protein · chain A against B, TM-score 0.30
- 2VXC · Structure of the CRB2-BRCT2 domain complex with phosphopeptide. · an experimental structure of the same protein · chain A against B, TM-score 0.30
- 2VXB · Structure of the Crb2-BRCT2 domain · an experimental structure of the same protein · chain A against A, TM-score 0.29
- 2VXB · Structure of the CRB2-BRCT2 domain · an experimental structure of the same protein · chain A against A, TM-score 0.29
- 4BU0 · Crystal structure of RAD4 BRCT1,2 in complex with a CRB2 phosphopeptide · an experimental structure of the same protein · chain A against C, TM-score 0.01
- 4BU0 · Crystal structure of Rad4 BRCT1,2 in complex with a Crb2 phosphopeptide · an experimental structure of the same protein · chain A against C, TM-score 0.01
- 4BU1 · Crystal structure of Rad4 BRCT1,2 in complex with a Crb2 phosphopeptide · an experimental structure of the same protein · chain A against C, TM-score 0.01
- 4BU1 · Crystal structure of RAD4 BRCT1,2 in complex with a CRB2 phosphopeptide · an experimental structure of the same protein · chain A against C, TM-score 0.01
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P87074
- Elsewhere: UniProt P87074 · AlphaFold DB P87074
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