Research workbench
AlphaFold monomer V2.0 prediction for rho GTPase-activating protein 35 (Q9NRY4)
Analyse AlphaFold monomer V2.0 prediction for rho GTPase-activating protein 35 (Q9NRY4) in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- Accession
- Q9NRY4
- Type
- protein
- Length
- 1,499 residues
- Chains
- 1
- Collection
- MolNFT v1 / AlphaFold
- Contract
- 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
- Owner
- 0x72863A6D5587eFC72E846eBb9C85252Bf5d4D642
- Molecule
- Rho GTPase-activating protein 35
- UniProt
- Q9NRY4
- Pockets
- 16 · best druggability 0.63
Structure
1 distinct chain · 40% helix, 10% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Rho GTPase-activating protein 35 | protein | 1499 | 40% helix, 10% strand | Q9NRY4 |
Pockets
16 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 363 | 0.63 | 0.78 | 40 | empty |
| 2 | 70 | 0.62 | 0.90 | 14 | empty |
| 3 | 68 | 0.61 | 0.90 | 19 | empty |
| 4 | 224 | 0.59 | 0.80 | 42 | empty |
| 5 | 212 | 0.48 | 0.74 | 26 | empty |
Compared structures
- 3C5H · Crystal structure of the Ras homolog domain of human GRLF1 (p190RhoGAP) · an experimental structure of the same protein · chain A against A, TM-score 0.15
- 3C5H · Crystal structure of the RAS homolog domain of human GRLF1 (P190RHOGAP) · an experimental structure of the same protein · chain A against A, TM-score 0.15
- 3FK2 · Crystal structure of the rhogap domain of human glucocorticoid receptor DNA-binding… · an experimental structure of the same protein · chain A against A, TM-score 0.13
- 3FK2 · Crystal structure of the RhoGAP domain of human glucocorticoid receptor DNA-binding… · an experimental structure of the same protein · chain A against A, TM-score 0.13
- 2K85 · P190-a rhogap FF1 domain · an experimental structure of the same protein · chain A against A, TM-score 0.04
- 2K85 · p190-A RhoGAP FF1 domain · an experimental structure of the same protein · chain A against A, TM-score 0.04
- 8DGQ · Crystal structure of p120RasGAP SH2-SH3-SH2 in complex with p190RhoGAP doubly… · an experimental structure of the same protein · chain A against U, TM-score 0.01
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9NRY4
- Elsewhere: UniProt Q9NRY4 · AlphaFold DB Q9NRY4
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