Research workbench
AlphaFold monomer V2.0 prediction for inactive rhomboid protein 2 (Q6PJF5)
Analyse AlphaFold monomer V2.0 prediction for inactive rhomboid protein 2 (Q6PJF5) in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- Accession
- Q6PJF5
- Type
- protein
- Length
- 856 residues
- Chains
- 1
- Collection
- MolNFT v1 / AlphaFold
- Contract
- 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
- Owner
- 0xaa53776A41fB2e67da75A96E8a53746b6874aAB4
- Molecule
- Inactive rhomboid protein 2
- UniProt
- Q6PJF5
- Pockets
- 4 · best druggability 0.79
Structure
1 distinct chain · 34% helix, 7% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Inactive rhomboid protein 2 | protein | 856 | 34% helix, 7% strand | Q6PJF5 |
Pockets
4 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 736 | 0.79 | 0.83 | 78 | empty |
| 2 | 667 | 0.76 | 0.82 | 71 | empty |
| 3 | 464 | 0.62 | 0.76 | 40 | empty |
| 4 | 87 | 0.37 | 0.75 | 12 | empty |
Modifications
Observed in the structure: 9 disulfide (disulfide).
Compared structures
- 8SNL · Structure of human ADAM17/iRhom2 sheddase complex · an experimental structure of the same protein · chain A against B, TM-score 0.56
- 8SNM · Structure of mature human ADAM17/iRhom2 sheddase complex in complex with ADAM17 prodomain · an experimental structure of the same protein · chain A against C, TM-score 0.56
- 8SNN · Structure of mature human ADAM17/iRhom2 sheddase complex, conformation 1 · an experimental structure of the same protein · chain A against B, TM-score 0.56
- 8SNO · Structure of mature human ADAM17/iRhom2 sheddase complex, conformation 2 · an experimental structure of the same protein · chain A against B, TM-score 0.56
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q6PJF5
- Elsewhere: UniProt Q6PJF5 · AlphaFold DB Q6PJF5
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