Research workbench
AlphaFold monomer V2.0 prediction for rest corepressor 1 (Q9UKL0)
Analyse AlphaFold monomer V2.0 prediction for rest corepressor 1 (Q9UKL0) in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- Accession
- Q9UKL0
- Type
- protein
- Length
- 485 residues
- Chains
- 1
- Collection
- MolNFT v1 / AlphaFold
- Contract
- 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
- Owner
- 0xbb2F1C7CB3A1eeFAc24fCa72cc627162D5413FD7
- Molecule
- Rest corepressor 1
- UniProt
- Q9UKL0
- Pockets
- 2 · best druggability 0.45
Structure
1 distinct chain · 39% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Rest corepressor 1 | protein | 485 | 39% helix, 0% strand | Q9UKL0 |
Pockets
2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 222 | 0.45 | 0.73 | 22 | empty |
| 2 | 64 | 0.30 | 0.74 | 11 | empty |
Compared structures
- 6S35 · LSD1/COREST1 complex with macrocyclic peptide inhibitor · an experimental structure of the same protein · chain A against B, TM-score 0.27
- 6S35 · LSD1/CoREST1 complex with macrocyclic peptide inhibitor · an experimental structure of the same protein · chain A against B, TM-score 0.27
- 5L3C · Human LSD1/CoREST: LSD1 E379K mutation · an experimental structure of the same protein · chain A against B, TM-score 0.27
- 5L3C · Human LSD1/COREST: LSD1 E379K mutation · an experimental structure of the same protein · chain A against B, TM-score 0.27
- 2UXX · Human LSD1 Histone Demethylase-CoREST in complex with an FAD- tranylcypromine adduct · an experimental structure of the same protein · chain A against B, TM-score 0.27
- 2UXX · Human LSD1 histone demethylase-corest in complex with an FAD- tranylcypromine adduct · an experimental structure of the same protein · chain A against B, TM-score 0.27
- 2V1D · Structural basis of LSD1-CoREST selectivity in histone H3 recognition · an experimental structure of the same protein · chain A against B, TM-score 0.27
- 2V1D · Structural basis of LSD1-corest selectivity in histone H3 recognition · an experimental structure of the same protein · chain A against B, TM-score 0.27
- 8Q1G · LSD1-CoREST bound to Acetylated K14 of Histone H3 · an experimental structure of the same protein · chain A against B, TM-score 0.27
- 2IW5 · Structural basis for corest-dependent demethylation of nucleosomes by the human LSD1… · an experimental structure of the same protein · chain A against B, TM-score 0.27
- 2IW5 · Structural Basis for CoREST-Dependent Demethylation of Nucleosomes by the Human LSD1… · an experimental structure of the same protein · chain A against B, TM-score 0.27
- 8YM7 · Crystal structure of Lysine Specific Demethylase 1 (LSD1) with JH-45 · an experimental structure of the same protein · chain A against B, TM-score 0.27
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9UKL0
- Elsewhere: UniProt Q9UKL0 · AlphaFold DB Q9UKL0
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