Research workbench
AlphaFold monomer V2.0 prediction for phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase pten (P60484)
Analyse AlphaFold monomer V2.0 prediction for phosphatidylinositol 3,4,5-trisphosphate… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- Accession
- P60484
- Type
- protein
- Length
- 403 residues
- Chains
- 1
- Collection
- MolNFT v1 / AlphaFold
- Contract
- 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
- Owner
- 0xA07F8d9D68124FDddD657b6fFA18449239Fb32Da
- Molecule
- Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein…
- UniProt
- P60484
- Pockets
- 4 · best druggability 0.76
Structure
1 distinct chain · 26% helix, 29% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase pten | protein | 403 | 26% helix, 29% strand | P60484 |
Pockets
4 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1049 | 0.76 | 0.79 | 89 | empty |
| 2 | 126 | 0.54 | 0.82 | 17 | empty |
| 3 | 152 | 0.53 | 0.80 | 28 | empty |
| 4 | 89 | 0.53 | 0.84 | 17 | empty |
Compared structures
- 7JUL · Crystal structure of non phosphorylated PTEN (n-crPTEN-13sp-T1, SDTTDSDPENEG) · an experimental structure of the same protein · chain A against A, TM-score 0.77
- 7JUL · Crystal structure of non phosphorylated pten (N-crpten-13SP-T1, sdttdsdpeneg) · an experimental structure of the same protein · chain A against A, TM-score 0.77
- 7JVX · Crystal structure of pten (aa 7-353 followed by spacer tgggsggtgggsggtgggcy ligated to… · an experimental structure of the same protein · chain A against A, TM-score 0.77
- 7JVX · Crystal structure of PTEN (aa 7-353 followed by spacer TGGGSGGTGGGSGGTGGGCY ligated to… · an experimental structure of the same protein · chain A against A, TM-score 0.77
- 5BUG · Crystal structure of human phosphatase PTEN oxidized by H2O2 · an experimental structure of the same protein · chain A against D, TM-score 0.77
- 5BUG · Crystal structure of human phosphatase pten oxidized by H2O2 · an experimental structure of the same protein · chain A against A, TM-score 0.76
- 5BZX · Crystal structure of human phosphatase PTEN treated with a bisperoxovanadium complex · an experimental structure of the same protein · chain A against D, TM-score 0.76
- 5BZZ · Crystal structure of human phosphatase pten in its reduced state · an experimental structure of the same protein · chain A against A, TM-score 0.76
- 5BZZ · Crystal structure of human phosphatase PTEN in its reduced state · an experimental structure of the same protein · chain A against A, TM-score 0.76
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P60484
- Elsewhere: UniProt P60484 · AlphaFold DB P60484
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