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AlphaFold monomer V2.0 prediction for pentatricopeptide repeat domain-containing protein 3, mitochondrial (Q96EY7)

Analyse AlphaFold monomer V2.0 prediction for pentatricopeptide repeat… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

Accession
Q96EY7
Type
protein
Length
689 residues
Chains
1
Collection
MolNFT v1 / AlphaFold
Contract
0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
Owner
0x5c4adF1416281C09AE8eE1cbb80fF7e44cE86F97
Molecule
Pentatricopeptide repeat domain-containing protein 3, mitochondrial
UniProt
Q96EY7
Pockets
5 · best druggability 0.71

Structure

1 distinct chain · 57% helix, 0% strand (DSSP).

ChainMoleculeTypeResiduesSecondary structureUniProt
APentatricopeptide repeat domain-containing protein 3, mitochondrialprotein68957% helix, 0% strandQ96EY7

Pockets

5 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

PocketVolume (ų)DruggabilityBuriednessLining residuesInside
17330.710.7870empty
21380.450.7725empty
31170.450.7817empty
41680.420.7323empty
5570.370.7917empty

Compared structures

  • 8K2A · Cryo-EM structure of the human 55S mitoribosome with Tigecycline · an experimental structure of the same protein · chain A against So, TM-score 0.89
  • 8XT2 · Cryo-EM structure of the human 55S mitoribosome with 10uM Tigecycline · an experimental structure of the same protein · chain A against So, TM-score 0.89
  • 8XT0 · Cryo-EM structure of the human 55S mitoribosome with 5um Tigecycline · an experimental structure of the same protein · chain A against So, TM-score 0.89
  • 8ANY · Human mitochondrial ribosome in complex with LRPPRC, SLIRP, A-site, P-site, E-site tRNAs… · an experimental structure of the same protein · chain A against A4, TM-score 0.84
  • 7PO3 · Human mitochondrial ribosome small subunit · an experimental structure of the same protein · chain A against 4, TM-score 0.84
  • 7PO2 · Initiation complex of human mitochondrial ribosome small subunit with IF2, fMet-tRNAMet… · an experimental structure of the same protein · chain A against 4, TM-score 0.84
  • 7P2E · Human mitochondrial ribosome small subunit in complex with IF3, GMPPMP and streptomycin · an experimental structure of the same protein · chain A against 4, TM-score 0.84
  • 7PO1 · Initiation complex of human mitochondrial ribosome small subunit with IF3 · an experimental structure of the same protein · chain A against 4, TM-score 0.84
  • 7PNZ · Assembly intermediate of human mitochondrial ribosome small subunit without mS37 in… · an experimental structure of the same protein · chain A against 4, TM-score 0.84
  • 7PNY · Assembly intermediate of human mitochondrial ribosome small subunit without mS37 in… · an experimental structure of the same protein · chain A against 4, TM-score 0.84
  • 7PO0 · Assembly intermediate of human mitochondrial ribosome small subunit without mS37 in… · an experimental structure of the same protein · chain A against 4, TM-score 0.84
  • 7PNX · Assembly intermediate of human mitochondrial ribosome small subunit without mS37 in… · an experimental structure of the same protein · chain A against 4, TM-score 0.84

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