Research workbench
AlphaFold monomer V2.0 prediction for presenilin-1 (P49768)
Analyse AlphaFold monomer V2.0 prediction for presenilin-1 (P49768) in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- Accession
- P49768
- Type
- protein
- Length
- 467 residues
- Chains
- 1
- Collection
- MolNFT v1 / AlphaFold
- Contract
- 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
- Owner
- 0x5c4adF1416281C09AE8eE1cbb80fF7e44cE86F97
- Molecule
- Presenilin-1
- UniProt
- P49768
- Pockets
- 4 · best druggability 0.80
Structure
1 distinct chain · 63% helix, 1% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Presenilin-1 | protein | 467 | 63% helix, 1% strand | P49768 |
Pockets
4 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1126 | 0.80 | 0.81 | 64 | empty |
| 2 | 299 | 0.62 | 0.79 | 32 | empty |
| 3 | 145 | 0.58 | 0.84 | 24 | empty |
| 4 | 78 | 0.31 | 0.73 | 14 | empty |
Compared structures
- 8OQZ · Structure of human gamma-secretase PSEN1 APH-1B isoform reconstituted into lipid nanodisc… · an experimental structure of the same protein · chain A against B, TM-score 0.66
- 6IYC · Recognition of the amyloid precursor protein by human gamma-secretase · an experimental structure of the same protein · chain A against B, TM-score 0.65
- 6IYC · Recognition of the Amyloid Precursor Protein by Human gamma-secretase · an experimental structure of the same protein · chain A against B, TM-score 0.65
- 6IDF · Cryo-EM structure of gamma secretase in complex with a Notch fragment · an experimental structure of the same protein · chain A against B, TM-score 0.65
- 6IDF · Cryo-EM structure of gamma secretase in complex with a notch fragment · an experimental structure of the same protein · chain A against B, TM-score 0.65
- 6LQG · Human gamma-secretase in complex with small molecule avagacestat · an experimental structure of the same protein · chain A against B, TM-score 0.65
- 6LQG · Human gamma-secretase in complex with small molecule Avagacestat · an experimental structure of the same protein · chain A against B, TM-score 0.65
- 8KCP · Cryo-EM structure of human gamma-secretase in complex with Crenigacestat · an experimental structure of the same protein · chain A against B, TM-score 0.65
- 6LR4 · Molecular basis for inhibition of human gamma-secretase by small molecule · an experimental structure of the same protein · chain A against B, TM-score 0.65
- 6LR4 · Molecular basis for inhibition of human gamma-secretase by small molecule · an experimental structure of the same protein · chain A against B, TM-score 0.65
- 7Y5T · CryoEM structure of PS1-containing gamma-secretase in complex with MRK-560 · an experimental structure of the same protein · chain A against B, TM-score 0.65
- 8KCO · Cryo-EM structure of human gamma-secretase in complex with RO4929097 · an experimental structure of the same protein · chain A against B, TM-score 0.65
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P49768
- Elsewhere: UniProt P49768 · AlphaFold DB P49768
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