AlphaFold monomer V2.0 prediction for 26S proteasome non-ATPase regulatory subunit 14 (O00487)

Structure

1 distinct chain · 45% helix, 18% strand (DSSP).

Pockets

3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Compared structures

• 8USB · Non-substrate-engaged human 26S proteasome with Nub1/FAT10 bound to Rpn1 · an experimental structure of the same protein · chain A against c, TM-score 0.87
• 9E8H · Human proteasome in resting state conformation bound to TXNL1 in backward conformation · an experimental structure of the same protein · chain A against c, TM-score 0.87
• 9E8I · Human proteasome in resting state conformation bound to TXNL1 in Forward conformation · an experimental structure of the same protein · chain A against c, TM-score 0.87
• 7W39 · Structure of USP14-bound human 26S proteasome in state EA2.1_UBL · an experimental structure of the same protein · chain A against c, TM-score 0.86
• 7W38 · Structure of USP14-bound human 26S proteasome in state EA2.0_UBL · an experimental structure of the same protein · chain A against c, TM-score 0.86
• 6MSE · Cryo-EM structures and dynamics of substrate-engaged human 26S proteasome · an experimental structure of the same protein · chain A against c, TM-score 0.86
• 8JTI · Cryo-EM structure of human 26S RP (Eb state) bound to K11/K48-branched ubiquitin (Ub)… · an experimental structure of the same protein · chain A against c, TM-score 0.86
• 7QXW · Proteasome-ZFAND5 Complex Z+D state · an experimental structure of the same protein · chain A against c, TM-score 0.86
• 6MSD · Cryo-EM structures and dynamics of substrate-engaged human 26S proteasome · an experimental structure of the same protein · chain A against c, TM-score 0.85
• 6WJD · SA-like state of human 26S Proteasome with non-cleavable M1-linked hexaubiquitin and E3… · an experimental structure of the same protein · chain A against c, TM-score 0.85
• 7QXU · Proteasome-ZFAND5 Complex Z+C state · an experimental structure of the same protein · chain A against c, TM-score 0.85
• 7QXP · Proteasome-ZFAND5 Complex Z+B state · an experimental structure of the same protein · chain A against c, TM-score 0.85

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt O00487
• Elsewhere: UniProt O00487 · AlphaFold DB O00487