AlphaFold monomer V2.0 prediction for 26S proteasome non-ATPase regulatory subunit 12 (O00232)

Structure

1 distinct chain · 74% helix, 2% strand (DSSP).

Pockets

3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Compared structures

• 8USB · Non-substrate-engaged human 26S proteasome with Nub1/FAT10 bound to Rpn1 · an experimental structure of the same protein · chain A against W, TM-score 0.94
• 9E8H · Human proteasome in resting state conformation bound to TXNL1 in backward conformation · an experimental structure of the same protein · chain A against W, TM-score 0.94
• 9E8I · Human proteasome in resting state conformation bound to TXNL1 in Forward conformation · an experimental structure of the same protein · chain A against W, TM-score 0.94
• 5L4K · The human 26S proteasome lid · an experimental structure of the same protein · chain A against P, TM-score 0.91
• 5L4K · The human 26S proteasome lid · an experimental structure of the same protein · chain A against P, TM-score 0.91
• 7W38 · Structure of USP14-bound human 26S proteasome in state EA2.0_UBL · an experimental structure of the same protein · chain A against W, TM-score 0.91
• 7W39 · Structure of USP14-bound human 26S proteasome in state EA2.1_UBL · an experimental structure of the same protein · chain A against W, TM-score 0.90
• 7W37 · Structure of USP14-bound human 26S proteasome in state EA1_UBL · an experimental structure of the same protein · chain A against W, TM-score 0.90
• 7QXP · Proteasome-ZFAND5 Complex Z+B state · an experimental structure of the same protein · chain A against W, TM-score 0.88
• 7QXU · Proteasome-ZFAND5 Complex Z+C state · an experimental structure of the same protein · chain A against W, TM-score 0.88
• 9E8O · Nub1/Fat10-processing human 26S proteasome bound to Txnl1 with Rpt2 at top of spiral… · an experimental structure of the same protein · chain A against W, TM-score 0.88
• 9E8N · Nub1/Fat10-processing human 26S proteasome bound to Txnl1 with Rpt3 at top of spiral… · an experimental structure of the same protein · chain A against W, TM-score 0.88

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt O00232
• Elsewhere: UniProt O00232 · AlphaFold DB O00232