Research workbench
AlphaFold monomer V2.0 prediction for pre-mRNA-splicing factor ATP- dependent RNA helicase PRP43 (P53131)
Analyse AlphaFold monomer V2.0 prediction for pre-mRNA-splicing factor ATP- dependent… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- Accession
- P53131
- Type
- protein
- Length
- 767 residues
- Chains
- 1
- Collection
- MolNFT v1 / AlphaFold
- Contract
- 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
- Owner
- 0xbb2F1C7CB3A1eeFAc24fCa72cc627162D5413FD7
- Molecule
- Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP43
- UniProt
- P53131
- Pockets
- 9 · best druggability 0.81
Structure
1 distinct chain · 43% helix, 16% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP43 | protein | 767 | 43% helix, 16% strand | P53131 |
Pockets
9 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1167 | 0.81 | 0.82 | 104 | empty |
| 2 | 301 | 0.66 | 0.82 | 48 | empty |
| 3 | 383 | 0.60 | 0.77 | 30 | empty |
| 4 | 112 | 0.60 | 0.86 | 27 | empty |
| 5 | 172 | 0.47 | 0.75 | 26 | empty |
Compared structures
- 3KX2 · Crystal structure of Prp43p in complex with ADP · an experimental structure of the same protein · chain A against B, TM-score 0.96
- 3KX2 · Crystal structure of PRP43P in complex with ADP · an experimental structure of the same protein · chain A against B, TM-score 0.96
- 2XAU · Crystal structure of the PRP43P deah-box RNA helicase in complex with ADP · an experimental structure of the same protein · chain A against A, TM-score 0.95
- 2XAU · Crystal structure of the Prp43p DEAH-box RNA helicase in complex with ADP · an experimental structure of the same protein · chain A against A, TM-score 0.95
- 5JPT · Crystal structure of the PRP43P deah-box RNA helicase in complex with cdp · an experimental structure of the same protein · chain A against A, TM-score 0.95
- 5JPT · Crystal structure of the PRP43P deah-box RNA helicase in complex with cdp · an experimental structure of the same protein · chain A against A, TM-score 0.95
- 5I8Q · S. cerevisiae Prp43 in complex with RNA and ADPNP · an experimental structure of the same protein · chain A against A, TM-score 0.94
- 5I8Q · S. cerevisiae PRP43 in complex with RNA and adpnp · an experimental structure of the same protein · chain A against A, TM-score 0.94
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P53131
- Elsewhere: UniProt P53131 · AlphaFold DB P53131
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