UniProt P53131
Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP43 (P53131)
Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP43 (UniProt P53131): 10 experimental structures and 1 predicted model on GenesisL1, 5 ligands bound, 15 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- P53131
- Protein
- Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP43
- Experimental structures
- 10
- Predicted models
- 1
- Ligands
- 5
- Pockets
- 15 · 2 records with a druggable one
Structures
11 records of P53131 in the MolNFT archive: 10 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2XAU | Crystal structure of the Prp43p DEAH-box RNA helicase in complex with ADP | x-ray diffraction | A, B | — | — |
| 2XAU | Crystal structure of the PRP43P deah-box RNA helicase in complex with ADP | x-ray diffraction | A, B | — | — |
| 3KX2 | Crystal structure of Prp43p in complex with ADP | x-ray diffraction | B, A | — | — |
| 3KX2 | Crystal structure of PRP43P in complex with ADP | x-ray diffraction | B, A | — | — |
| 5I8Q | S. cerevisiae Prp43 in complex with RNA and ADPNP | x-ray diffraction | A, B | MG, ANP | — |
| 5I8Q | S. cerevisiae PRP43 in complex with RNA and adpnp | x-ray diffraction | A, B | — | — |
| 5JPT | Crystal structure of the PRP43P deah-box RNA helicase in complex with cdp | x-ray diffraction | A, B | CDP, MG, NI | — |
| 5JPT | Crystal structure of the PRP43P deah-box RNA helicase in complex with cdp | x-ray diffraction | A, B | — | — |
| 5Y88 | Cryo-EM structure of the intron-lariat spliceosome ready for disassembly from S.CEREVISIAE at 3.5… | electron microscopy | W | — | — |
| 8RDY | Saccharomyces cerevisiae Prp43 helicase in complex with Pxr1 | electron microscopy | A | ADP, MG | 6 (best 0.72) |
| P53131 | AlphaFold monomer V2.0 prediction for pre-mRNA-splicing factor ATP- dependent RNA helicase PRP43… | predicted | A | — | 9 (best 0.81) |
Ligands
Experiment against prediction
- 2XAU chain B against the predicted model P53131: TM-score 0.98, RMSD 1.47 Å
- 2XAU chain B against the predicted model P53131: TM-score 0.98, RMSD 1.47 Å
- 2XAU chain A against the predicted model P53131: TM-score 0.98, RMSD 1.48 Å
- 2XAU chain A against the predicted model P53131: TM-score 0.98, RMSD 1.48 Å
- 5JPT chain A against the predicted model P53131: TM-score 0.98, RMSD 1.49 Å
- 5JPT chain A against the predicted model P53131: TM-score 0.98, RMSD 1.49 Å
- 5JPT chain B against the predicted model P53131: TM-score 0.97, RMSD 1.56 Å
- 5JPT chain B against the predicted model P53131: TM-score 0.97, RMSD 1.56 Å
- 3KX2 chain B against the predicted model P53131: TM-score 0.97, RMSD 1.50 Å
- 3KX2 chain B against the predicted model P53131: TM-score 0.97, RMSD 1.50 Å
Elsewhere
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