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AlphaFold monomer V2.0 prediction for pre-mRNA-processing factor 19 (Q9UMS4)

Analyse AlphaFold monomer V2.0 prediction for pre-mRNA-processing factor 19 (Q9UMS4) in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

Accession
Q9UMS4
Type
protein
Length
504 residues
Chains
1
Collection
MolNFT v1 / AlphaFold
Contract
0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
Owner
0x9B130d619fCFc21d0D08E5Ce38Cf42A5fbe230CB
Molecule
Pre-mRNA-processing factor 19
UniProt
Q9UMS4
Pockets
3 · best druggability 0.80

Structure

1 distinct chain · 22% helix, 33% strand (DSSP).

ChainMoleculeTypeResiduesSecondary structureUniProt
APre-mRNA-processing factor 19protein50422% helix, 33% strandQ9UMS4

Pockets

3 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

PocketVolume (ų)DruggabilityBuriednessLining residuesInside
17930.800.8465empty
23080.580.7733empty
3850.390.7720empty

Compared structures

  • 4LG8 · Crystal structure of PRPF19 WD40 repeats · an experimental structure of the same protein · chain A against A, TM-score 0.61
  • 4LG8 · Crystal structure of PRPF19 WD40 repeats · an experimental structure of the same protein · chain A against A, TM-score 0.61
  • 5YZG · The Cryo-EM Structure of Human Catalytic Step I Spliceosome (C complex) at 4.1 angstrom… · an experimental structure of the same protein · chain A against s, TM-score 0.61
  • 8C6J · Human spliceosomal PM5 C* complex · an experimental structure of the same protein · chain A against v, TM-score 0.24
  • 9FMD · Integrative model of the human post-catalytic spliceosome (P-complex) · an experimental structure of the same protein · chain A against s, TM-score 0.24
  • 8RO2 · Integrative Structure of the human intron lariat Spliceosome (ILS'') · an experimental structure of the same protein · chain A against s, TM-score 0.24
  • 8I0V · The cryo-EM structure of human post-Bact complex · an experimental structure of the same protein · chain A against r, TM-score 0.24
  • 8I0W · The cryo-EM structure of human C complex · an experimental structure of the same protein · chain A against r, TM-score 0.24
  • 8I0U · The cryo-EM structure of human Bact-IV complex · an experimental structure of the same protein · chain A against r, TM-score 0.24
  • 7W59 · The cryo-EM structure of human pre-C*-I complex · an experimental structure of the same protein · chain A against r, TM-score 0.24
  • 7W59 · The cryo-EM structure of human pre-C*-I complex · an experimental structure of the same protein · chain A against r, TM-score 0.24
  • 7W5B · The cryo-EM structure of human C* complex · an experimental structure of the same protein · chain A against r, TM-score 0.24

Analyse

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