Research workbench
AlphaFold monomer V2.0 prediction for SERINE/THREONINE-protein phosphatase 2B catalytic subunit alpha isoform (Q08209)
Analyse AlphaFold monomer V2.0 prediction for SERINE/THREONINE-protein phosphatase 2B… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- Accession
- Q08209
- Type
- protein
- Length
- 521 residues
- Chains
- 1
- Collection
- MolNFT v1 / AlphaFold
- Contract
- 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
- Owner
- 0x78Cc7f9BF18AF8279e492D45EE7Fe9d7cC6f6D07
- Molecule
- SERINE/THREONINE-protein phosphatase 2B catalytic subunit alpha isoform
- UniProt
- Q08209
- Pockets
- 3 · best druggability 0.72
Structure
1 distinct chain · 41% helix, 12% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | SERINE/THREONINE-protein phosphatase 2B catalytic subunit alpha isoform | protein | 521 | 41% helix, 12% strand | Q08209 |
Pockets
3 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 683 | 0.72 | 0.78 | 67 | empty |
| 2 | 143 | 0.55 | 0.81 | 35 | empty |
| 3 | 79 | 0.33 | 0.74 | 12 | empty |
Compared structures
- 1AUI · Human calcineurin heterodimer · an experimental structure of the same protein · chain A against A, TM-score 0.71
- 1AUI · Human calcineurin heterodimer · an experimental structure of the same protein · chain A against A, TM-score 0.71
- 6NUC · Structure of calcineurin in complex with NHE1 peptide · an experimental structure of the same protein · chain A against A, TM-score 0.68
- 6NUU · Structure of calcineurin mutant in complex with NHE1 peptide · an experimental structure of the same protein · chain A against A, TM-score 0.68
- 6NUF · Structure of calcineurin in complex with NHE1 peptide · an experimental structure of the same protein · chain A against A, TM-score 0.68
- 5SVE · Structure of calcineurin in complex with NFATC1 lxvp peptide · an experimental structure of the same protein · chain A against A, TM-score 0.67
- 2P6B · Crystal structure of human calcineurin in complex with pvivit peptide · an experimental structure of the same protein · chain A against A, TM-score 0.67
- 2P6B · Crystal Structure of Human Calcineurin in Complex with PVIVIT Peptide · an experimental structure of the same protein · chain A against A, TM-score 0.67
- 3LL8 · Crystal Structure of Calcineurin in Complex with AKAP79 Peptide · an experimental structure of the same protein · chain A against A, TM-score 0.67
- 3LL8 · Crystal structure of calcineurin in complex with AKAP79 peptide · an experimental structure of the same protein · chain A against A, TM-score 0.67
- 4F0Z · Crystal Structure of Calcineurin in Complex with the Calcineurin-Inhibiting Domain of the… · an experimental structure of the same protein · chain A against A, TM-score 0.67
- 4F0Z · Crystal structure of calcineurin in complex with the calcineurin- inhibiting domain of… · an experimental structure of the same protein · chain A against A, TM-score 0.67
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q08209
- Elsewhere: UniProt Q08209 · AlphaFold DB Q08209
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