Research workbench
AlphaFold monomer V2.0 prediction for SERINE/THREONINE-protein kinase PLK4 (O00444)
Analyse AlphaFold monomer V2.0 prediction for SERINE/THREONINE-protein kinase PLK4… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- Accession
- O00444
- Type
- protein
- Length
- 970 residues
- Chains
- 1
- Collection
- MolNFT v1 / AlphaFold
- Contract
- 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
- Owner
- 0xa73BAb1DabE4333A884D03393eAa10c3B4215494
- Molecule
- SERINE/THREONINE-protein kinase PLK4
- UniProt
- O00444
- Pockets
- 5 · best druggability 0.69
Structure
1 distinct chain · 19% helix, 16% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | SERINE/THREONINE-protein kinase PLK4 | protein | 970 | 19% helix, 16% strand | O00444 |
Pockets
5 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1080 | 0.69 | 0.74 | 97 | empty |
| 2 | 288 | 0.64 | 0.81 | 32 | empty |
| 3 | 137 | 0.56 | 0.82 | 16 | empty |
| 4 | 132 | 0.38 | 0.74 | 19 | empty |
| 5 | 105 | 0.35 | 0.73 | 15 | empty |
Compared structures
- 3COK · Crystal structure of PLK4 kinase · an experimental structure of the same protein · chain A against B, TM-score 0.23
- 3COK · Crystal structure of PLK4 kinase · an experimental structure of the same protein · chain A against B, TM-score 0.23
- 8XPG · The Crystal Structure of polo box domain of Plk4 from Biortus. · an experimental structure of the same protein · chain A against B, TM-score 0.23
- 4N9J · Crystal structure of the cryptic polo box domain of human Plk4 · an experimental structure of the same protein · chain A against A, TM-score 0.23
- 4N9J · Crystal structure of the cryptic polo box domain of human PLK4 · an experimental structure of the same protein · chain A against A, TM-score 0.23
- 6W3I · Crystal structure of a FAM46C mutant in complex with Plk4 · an experimental structure of the same protein · chain A against B, TM-score 0.23
- 6W3I · Crystal structure of a FAM46C mutant in complex with PLK4 · an experimental structure of the same protein · chain A against B, TM-score 0.23
- 4N7V · Crystal structure of human Plk4 cryptic polo box (CPB) in complex with a Cep152… · an experimental structure of the same protein · chain A against A, TM-score 0.23
- 4N7V · Crystal structure of human PLK4 cryptic polo box (cpb) in complex with a CEP152… · an experimental structure of the same protein · chain A against A, TM-score 0.23
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O00444
- Elsewhere: UniProt O00444 · AlphaFold DB O00444
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