Research workbench
AlphaFold monomer V2.0 prediction for phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform (Q8BTI9)
Analyse AlphaFold monomer V2.0 prediction for phosphatidylinositol 4,5-bisphosphate… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- Accession
- Q8BTI9
- Type
- protein
- Length
- 1,064 residues
- Chains
- 1
- Collection
- MolNFT v1 / AlphaFold
- Contract
- 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
- Owner
- 0x767E841c23C1fCf898B47f3029614c98232Bf0FC
- Molecule
- Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
- UniProt
- Q8BTI9
- Pockets
- 13 · best druggability 0.82
Structure
1 distinct chain · 45% helix, 19% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | protein | 1064 | 45% helix, 19% strand | Q8BTI9 |
Pockets
13 pockets found on a 1 Å grid, 8 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1116 | 0.82 | 0.83 | 75 | empty |
| 2 | 950 | 0.78 | 0.80 | 104 | empty |
| 3 | 928 | 0.78 | 0.80 | 104 | empty |
| 4 | 531 | 0.66 | 0.77 | 55 | empty |
| 5 | 193 | 0.54 | 0.78 | 29 | empty |
Compared structures
- 2Y3A · Crystal structure of p110beta in complex with icSH2 of p85beta and the drug GDC-0941 · an experimental structure of the same protein · chain A against A, TM-score 0.88
- 2Y3A · Crystal structure of P110BETA in complex with ICSH2 of P85BETA and the drug gdc-0941 · an experimental structure of the same protein · chain A against A, TM-score 0.88
- 4BFR · Discovery and Optimization of Pyrimidone Indoline Amide PI3Kbeta Inhibitors for the… · an experimental structure of the same protein · chain A against B, TM-score 0.77
- 4BFR · Discovery and optimization of pyrimidone indoline amide PI3KBETA inhibitors for the… · an experimental structure of the same protein · chain A against B, TM-score 0.77
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q8BTI9
- Elsewhere: UniProt Q8BTI9 · AlphaFold DB Q8BTI9
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