UniProt Q8BTI9
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform (Q8BTI9)
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform (UniProt Q8BTI9): 4 experimental structures and 1 predicted model on GenesisL1, 13 pockets. Binding sites, druggability and experiment against…
- UniProt
- Q8BTI9
- Protein
- Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
- Experimental structures
- 4
- Predicted models
- 1
- Pockets
- 13 · 1 record with a druggable one
Structures
5 records of Q8BTI9 in the MolNFT archive: 4 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2Y3A | Crystal structure of p110beta in complex with icSH2 of p85beta and the drug GDC-0941 | x-ray diffraction | A | — | — |
| 2Y3A | Crystal structure of P110BETA in complex with ICSH2 of P85BETA and the drug gdc-0941 | x-ray diffraction | A | — | — |
| 4BFR | Discovery and Optimization of Pyrimidone Indoline Amide PI3Kbeta Inhibitors for the Treatment of… | x-ray diffraction | A, B | — | — |
| 4BFR | Discovery and optimization of pyrimidone indoline amide PI3KBETA inhibitors for the treatment of… | x-ray diffraction | A, B | — | — |
| Q8BTI9 | AlphaFold monomer V2.0 prediction for phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic… | predicted | A | — | 13 (best 0.82) |
Experiment against prediction
- 4BFR chain B against the predicted model Q8BTI9: TM-score 0.98, RMSD 1.57 Å
- 4BFR chain B against the predicted model Q8BTI9: TM-score 0.98, RMSD 1.57 Å
- 2Y3A chain A against the predicted model Q8BTI9: TM-score 0.96, RMSD 2.40 Å
- 2Y3A chain A against the predicted model Q8BTI9: TM-score 0.96, RMSD 2.40 Å
- 4BFR chain A against the predicted model Q8BTI9: TM-score 0.95, RMSD 2.38 Å
- 4BFR chain A against the predicted model Q8BTI9: TM-score 0.95, RMSD 2.38 Å
Elsewhere
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