Research workbench
AlphaFold monomer V2.0 prediction for phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (P42336)
Analyse AlphaFold monomer V2.0 prediction for phosphatidylinositol 4,5-bisphosphate… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- Accession
- P42336
- Type
- protein
- Length
- 1,068 residues
- Chains
- 1
- Collection
- MolNFT v1 / AlphaFold
- Contract
- 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
- Owner
- 0x35612D34a32C306CA4fc1edA9360D1F717e25950
- Molecule
- Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
- UniProt
- P42336
- Pockets
- 14 · best druggability 0.85
Structure
1 distinct chain · 43% helix, 19% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform | protein | 1068 | 43% helix, 19% strand | P42336 |
Pockets
14 pockets found on a 1 Å grid, 7 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 832 | 0.85 | 0.87 | 84 | empty |
| 2 | 514 | 0.68 | 0.78 | 46 | empty |
| 3 | 351 | 0.67 | 0.81 | 53 | empty |
| 4 | 524 | 0.67 | 0.78 | 65 | empty |
| 5 | 245 | 0.65 | 0.82 | 25 | empty |
Compared structures
- 5SXB · Crystal structure of PI3KALPHA in complex with fragment 23 · an experimental structure of the same protein · chain A against A, TM-score 0.95
- 5SWP · Crystal Structure of PI3Kalpha in complex with fragments 6 and 24 · an experimental structure of the same protein · chain A against A, TM-score 0.95
- 5SWP · Crystal structure of PI3KALPHA in complex with fragments 6 and 24 · an experimental structure of the same protein · chain A against A, TM-score 0.95
- 5SWT · Crystal Structure of PI3Kalpha in complex with fragments 17 and 27 · an experimental structure of the same protein · chain A against A, TM-score 0.95
- 5SWT · Crystal structure of PI3KALPHA in complex with fragments 17 and 27 · an experimental structure of the same protein · chain A against A, TM-score 0.95
- 5SWO · Crystal structure of PI3KALPHA in complex with fragments 4 and 19 · an experimental structure of the same protein · chain A against A, TM-score 0.95
- 5SXA · Crystal Structure of PI3Kalpha in complex with fragment 10 · an experimental structure of the same protein · chain A against A, TM-score 0.95
- 5SXA · Crystal structure of PI3KALPHA in complex with fragment 10 · an experimental structure of the same protein · chain A against A, TM-score 0.95
- 7PG5 · Crystal structure of PI3KALPHA · an experimental structure of the same protein · chain A against A, TM-score 0.95
- 5SX8 · Crystal structure of PI3KALPHA in complex with fragments 12 and 15 · an experimental structure of the same protein · chain A against A, TM-score 0.95
- 5SWR · Crystal structure of PI3KALPHA in complex with fragments 20 and 26 · an experimental structure of the same protein · chain A against A, TM-score 0.95
- 7PG6 · Crystal structure of PI3KALPHA in complex with the inhibitor nvp- BYL719 · an experimental structure of the same protein · chain A against A, TM-score 0.95
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P42336
- Elsewhere: UniProt P42336 · AlphaFold DB P42336
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