MolNFT v1 · #185137 · protein
Crystal structure of PI3KALPHA in complex with the inhibitor nvp- BYL719
7PG6: “Crystal structure of PI3KALPHA in complex with the inhibitor nvp- BYL719”. X-ray diffraction, 2 ligands (1LT, NA). MolNFT v1 #185137 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 7PG6
- Type
- protein
- Length
- 1,292 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- UniProt
- P42336, P27986
- Ligands
- 1LT, NA
Structure
x-ray diffraction · 2 distinct chains.
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | — | protein | 1026 | — | P42336 |
| B | — | protein | 266 | — | P27986 |
Ligands and binding sites
- 1LT · (2S)-N~1~-{4-methyl-5-[2-(1,1,1-trifluoro-2-methylpropan-2-yl)pyridin-4-yl]-1,3-thiazol-2-yl}pyrrolidine-1,2-dicarboxamide · ligand · chains A
- NA · Sodium ion · metal · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Compared structures
- 7PG6 · Crystal Structure of PI3Kalpha in complex with the inhibitor NVP-BYL719 · the same entry in another collection · chain A against A, TM-score 1.00
- P42336 · AlphaFold monomer V2.0 prediction for phosphatidylinositol 4,5-bisphosphate 3-kinase… · a predicted model of the same protein · chain A against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P42336
- Every structure of UniProt P27986
- Elsewhere: RCSB PDB 7PG6 · PDBe 7PG6 · UniProt P42336 · UniProt P27986
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