Research workbench
AlphaFold monomer V2.0 prediction for lysine-specific demethylase PHF2 (O75151)
Analyse AlphaFold monomer V2.0 prediction for lysine-specific demethylase PHF2 (O75151) in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- Accession
- O75151
- Type
- protein
- Length
- 1,096 residues
- Chains
- 1
- Collection
- MolNFT v1 / AlphaFold
- Contract
- 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
- Owner
- 0xea70C1c161ad1752A036904c1B96f7dCc33d1aFb
- Molecule
- Lysine-specific demethylase PHF2
- UniProt
- O75151
- Pockets
- 5 · best druggability 0.76
Structure
1 distinct chain · 21% helix, 9% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Lysine-specific demethylase PHF2 | protein | 1096 | 21% helix, 9% strand | O75151 |
Pockets
5 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 442 | 0.76 | 0.85 | 43 | empty |
| 2 | 155 | 0.42 | 0.74 | 25 | empty |
| 3 | 80 | 0.40 | 0.78 | 16 | empty |
| 4 | 109 | 0.35 | 0.73 | 16 | empty |
| 5 | 51 | 0.32 | 0.77 | 17 | empty |
Compared structures
- 8F8Y · PHF2 (PHD+JMJ) in Complex with VRK1 N-Terminal Peptide · an experimental structure of the same protein · chain A against B, TM-score 0.33
- 8F8Z · PHF2 (PHD+JMJ) in Complex with H3 Histone N-Terminal Peptide · an experimental structure of the same protein · chain A against B, TM-score 0.33
- 3PTR · PHF2 Jumonji domain · an experimental structure of the same protein · chain A against B, TM-score 0.33
- 3PTR · PHF2 jumonji domain · an experimental structure of the same protein · chain A against B, TM-score 0.33
- 3PU8 · PHF2 Jumonji-NOG-Fe(II) complex · an experimental structure of the same protein · chain A against B, TM-score 0.33
- 3PU8 · PHF2 jumonji-nog-FE(II) complex · an experimental structure of the same protein · chain A against B, TM-score 0.33
- 3PUA · PHF2 Jumonji-NOG-Ni(II) · an experimental structure of the same protein · chain A against A, TM-score 0.33
- 3PUA · PHF2 jumonji-nog-NI(II) · an experimental structure of the same protein · chain A against A, TM-score 0.33
- 3PUS · PHF2 jumonji-nog-NI(II) · an experimental structure of the same protein · chain A against A, TM-score 0.33
- 3PUS · PHF2 Jumonji-NOG-Ni(II) · an experimental structure of the same protein · chain A against A, TM-score 0.33
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O75151
- Elsewhere: UniProt O75151 · AlphaFold DB O75151
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