UniProt O75151
Lysine-specific demethylase PHF2 (O75151)
Lysine-specific demethylase PHF2 (UniProt O75151), EC 1.14.11.-: 16 experimental structures and 1 predicted model on GenesisL1, 2 ligands bound, 33 pockets. Binding sites, druggability and experiment against prediction (TM-score)…
- UniProt
- O75151
- Protein
- Lysine-specific demethylase PHF2
- EC
- 1.14.11.-
- Experimental structures
- 16
- Predicted models
- 1
- Ligands
- 2
- Pockets
- 33 · 3 records with a druggable one
Structures
17 records of O75151 in the MolNFT archive: 16 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 3KQI | crystal structure of PHF2 PHD domain complexed with H3K4Me3 peptide | x-ray diffraction | A | — | — |
| 3KQI | Crystal structure of PHF2 phd domain complexed with H3K4ME3 peptide | x-ray diffraction | A | — | — |
| 3PTR | PHF2 Jumonji domain | x-ray diffraction | B | — | — |
| 3PTR | PHF2 jumonji domain | x-ray diffraction | B | — | — |
| 3PU3 | PHF2 Jumonji domain-NOG complex | x-ray diffraction | A, B | — | — |
| 3PU3 | PHF2 jumonji domain-nog complex | x-ray diffraction | A, B | — | — |
| 3PU8 | PHF2 Jumonji-NOG-Fe(II) complex | x-ray diffraction | B, A | — | — |
| 3PU8 | PHF2 jumonji-nog-FE(II) complex | x-ray diffraction | B, A | — | — |
| 3PUA | PHF2 Jumonji-NOG-Ni(II) | x-ray diffraction | A | — | — |
| 3PUA | PHF2 jumonji-nog-NI(II) | x-ray diffraction | A | — | — |
| 3PUS | PHF2 Jumonji-NOG-Ni(II) | x-ray diffraction | A, B | — | — |
| 3PUS | PHF2 jumonji-nog-NI(II) | x-ray diffraction | A, B | — | — |
| 7M10 | PHF2 PHD Domain Complexed with Peptide From N-terminus of VRK1 | x-ray diffraction | A | ZN | — |
| 7M10 | PHF2 phd domain complexed with peptide from N-terminus of VRK1 | x-ray diffraction | A | ZN | — |
| 8F8Y | PHF2 (PHD+JMJ) in Complex with VRK1 N-Terminal Peptide | x-ray diffraction | A, B | ZN, SO4 | 15 (best 0.80) |
| 8F8Z | PHF2 (PHD+JMJ) in Complex with H3 Histone N-Terminal Peptide | x-ray diffraction | A, B | ZN, SO4 | 13 (best 0.80) |
| O75151 | AlphaFold monomer V2.0 prediction for lysine-specific demethylase PHF2 (O75151) | predicted | A | — | 5 (best 0.76) |
Ligands
Experiment against prediction
- 3PU8 chain B against the predicted model O75151: TM-score 0.99, RMSD 0.82 Å
- 3PU8 chain B against the predicted model O75151: TM-score 0.99, RMSD 0.82 Å
- 3PTR chain B against the predicted model O75151: TM-score 0.99, RMSD 0.86 Å
- 3PTR chain B against the predicted model O75151: TM-score 0.99, RMSD 0.86 Å
- 3PUA chain A against the predicted model O75151: TM-score 0.99, RMSD 0.86 Å
- 3PUA chain A against the predicted model O75151: TM-score 0.99, RMSD 0.86 Å
- 3PUS chain A against the predicted model O75151: TM-score 0.99, RMSD 0.87 Å
- 3PUS chain A against the predicted model O75151: TM-score 0.99, RMSD 0.87 Å
- 3PUS chain B against the predicted model O75151: TM-score 0.98, RMSD 0.95 Å
- 3PUS chain B against the predicted model O75151: TM-score 0.98, RMSD 0.95 Å
Elsewhere
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