AlphaFold monomer V2.0 prediction for phospholipase A2, membrane associated (P14555)

Structure

1 distinct chain · 53% helix, 7% strand (DSSP).

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Modifications

Observed in the structure: 7 disulfide (disulfide).

Compared structures

• 1KVO · Human phospholipase A2 complexed with a highly potent substrate anologue · an experimental structure of the same protein · chain A against A, TM-score 0.85
• 1KVO · Human phospholipase A2 complexed with a highly potent substrate anologue · an experimental structure of the same protein · chain A against A, TM-score 0.85
• 5G3N · Discovery of a novel secreted phospholipase A2 (sPLA2) inhibitor. · an experimental structure of the same protein · chain A against A, TM-score 0.85
• 5G3N · Discovery of a novel secreted phospholipase A2 (SPLA2) inhibitor. · an experimental structure of the same protein · chain A against A, TM-score 0.85
• 1KQU · Human phospholipase A2 complexed with a substrate anologue · an experimental structure of the same protein · chain A against A, TM-score 0.85
• 1KQU · Human phospholipase A2 complexed with a substrate anologue · an experimental structure of the same protein · chain A against A, TM-score 0.85
• 3U8H · Functionally selective inhibition of Group IIA phospholipase A2 reveals a role for… · an experimental structure of the same protein · chain A against A, TM-score 0.85
• 3U8H · Functionally selective inhibition of group iia phospholipase A2 reveals a role for… · an experimental structure of the same protein · chain A against A, TM-score 0.85
• 1J1A · Pancreatic secretory phospholipase A2 (iia) with anti- inflammatory activity · an experimental structure of the same protein · chain A against A, TM-score 0.85
• 1J1A · PANCREATIC SECRETORY PHOSPHOLIPASE A2 (IIa) WITH ANTI-INFLAMMATORY ACTIVITY · an experimental structure of the same protein · chain A against A, TM-score 0.85
• 1DCY · Crystal structure of human S-PLA2 in complex with indole 3 active site inhibitor · an experimental structure of the same protein · chain A against A, TM-score 0.85
• 1DCY · Crystal structure of human S-PLA2 in complex with indole 3 active site inhibitor · an experimental structure of the same protein · chain A against A, TM-score 0.85

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt P14555
• Elsewhere: UniProt P14555 · AlphaFold DB P14555