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AlphaFold monomer V2.0 prediction for cytosolic phospholipase A2 delta (Q86XP0)

Analyse AlphaFold monomer V2.0 prediction for cytosolic phospholipase A2 delta (Q86XP0) in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

Accession
Q86XP0
Type
protein
Length
818 residues
Chains
1
Collection
MolNFT v1 / AlphaFold
Contract
0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
Owner
0xa73BAb1DabE4333A884D03393eAa10c3B4215494
Molecule
Cytosolic phospholipase A2 delta
UniProt
Q86XP0
Pockets
9 · best druggability 0.74

Structure

1 distinct chain · 30% helix, 26% strand (DSSP).

ChainMoleculeTypeResiduesSecondary structureUniProt
ACytosolic phospholipase A2 deltaprotein81830% helix, 26% strandQ86XP0

Pockets

9 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.

PocketVolume (ų)DruggabilityBuriednessLining residuesInside
1890.740.9624empty
21100.630.8826empty
31950.540.7932empty
41840.510.7830empty
5880.510.8320empty

Modifications

Observed in the structure: 1 disulfide (disulfide).

Compared structures

  • 5IZ5 · Human givd cytosolic phospholipase A2 · an experimental structure of the same protein · chain A against A, TM-score 0.92
  • 5IZ5 · Human GIVD cytosolic phospholipase A2 · an experimental structure of the same protein · chain A against A, TM-score 0.92
  • 5IZR · Human GIVD cytosolic phospholipase A2 in complex with Methyl gamma-Linolenyl… · an experimental structure of the same protein · chain A against B, TM-score 0.78
  • 5IZR · Human givd cytosolic phospholipase A2 in complex with methyl gamma- linolenyl… · an experimental structure of the same protein · chain A against B, TM-score 0.78
  • 5IXC · Human GIVD cytosolic phospholipase A2 in complex with Methyl gamma-Linolenyl… · an experimental structure of the same protein · chain A against A, TM-score 0.78
  • 5IXC · Human givd cytosolic phospholipase A2 in complex with methyl gamma- linolenyl… · an experimental structure of the same protein · chain A against A, TM-score 0.78

Analyse

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