Research workbench
AlphaFold monomer V2.0 prediction for P2X purinoceptor 1 (P51575)
Analyse AlphaFold monomer V2.0 prediction for P2X purinoceptor 1 (P51575) in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- Accession
- P51575
- Type
- protein
- Length
- 399 residues
- Chains
- 1
- Collection
- MolNFT v1 / AlphaFold
- Contract
- 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
- Owner
- 0x9E8f38861a94B258527337e479546317Bd75Fb49
- Molecule
- P2X purinoceptor 1
- UniProt
- P51575
- Pockets
- 3 · best druggability 0.44
Structure
1 distinct chain · 33% helix, 34% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | P2X purinoceptor 1 | protein | 399 | 33% helix, 34% strand | P51575 |
Pockets
3 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 129 | 0.44 | 0.76 | 20 | empty |
| 2 | 65 | 0.32 | 0.75 | 12 | empty |
| 3 | 62 | 0.31 | 0.75 | 15 | empty |
Modifications
Observed in the structure: 5 disulfide (disulfide).
Compared structures
- 9C2B · Cryo-EM structure of the human P2X1 receptor in the ATP-bound desensitized state · an experimental structure of the same protein · chain A against B, TM-score 0.81
- 9B73 · Cryo-EM structure of the desensitised ATP-bound human P2X1 receptor · an experimental structure of the same protein · chain A against A, TM-score 0.79
- 9B95 · Cryo-EM structure of the closed NF449-bound human P2X1 receptor · an experimental structure of the same protein · chain A against B, TM-score 0.76
- 9C2A · Cryo-EM structure of the human P2X1 receptor in the apo closed state · an experimental structure of the same protein · chain A against B, TM-score 0.76
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P51575
- Elsewhere: UniProt P51575 · AlphaFold DB P51575
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