UniProt P51575
P2X purinoceptor 1 (P51575)
P2X purinoceptor 1 (UniProt P51575): 4 experimental structures and 1 predicted model on GenesisL1, 5 ligands bound, 53 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P51575
- Protein
- P2X purinoceptor 1
- Experimental structures
- 4
- Predicted models
- 1
- Ligands
- 5
- Pockets
- 53 · 4 records with a druggable one
Structures
5 records of P51575 in the MolNFT archive: 4 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 9B73 | Cryo-EM structure of the desensitised ATP-bound human P2X1 receptor | electron microscopy | A, B, C | ATP, NAG, MG | 13 (best 0.88) |
| 9C2A | Cryo-EM structure of the human P2X1 receptor in the apo closed state | electron microscopy | A, B, C | NAG, Y01 | 12 (best 0.87) |
| 9C2B | Cryo-EM structure of the human P2X1 receptor in the ATP-bound desensitized state | electron microscopy | A, B, C | NAG, MG, ATP | 14 (best 0.87) |
| 9C2C | Cryo-EM structure of the human P2X1 receptor in the NF449-bound inhibited state | electron microscopy | A, C, B | NAG, A1ALI | 11 (best 0.86) |
| P51575 | AlphaFold monomer V2.0 prediction for P2X purinoceptor 1 (P51575) | predicted | A | — | 3 (best 0.44) |
Ligands
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · in 4 records
- ATP · Adenosine-5'-triphosphate · in 2 records
- MG · Magnesium ion · in 2 records
- A1ALI · 4,4',4'',4'''-{carbonylbis[azanediylbenzene-5,1,3-triylbis(carbonylazanediyl)]}tetra(benzene-1,3-disulfonic acid) · in 1 record
- Y01 · Cholesterol hemisuccinate · in 1 record
Experiment against prediction
- 9C2B chain B against the predicted model P51575: TM-score 0.97, RMSD 1.17 Å
- 9C2B chain C against the predicted model P51575: TM-score 0.97, RMSD 1.17 Å
- 9C2B chain A against the predicted model P51575: TM-score 0.97, RMSD 1.17 Å
- 9C2A chain B against the predicted model P51575: TM-score 0.97, RMSD 1.26 Å
- 9C2A chain A against the predicted model P51575: TM-score 0.97, RMSD 1.26 Å
- 9C2A chain C against the predicted model P51575: TM-score 0.97, RMSD 1.26 Å
- 9B73 chain A against the predicted model P51575: TM-score 0.96, RMSD 1.36 Å
- 9B73 chain B against the predicted model P51575: TM-score 0.96, RMSD 1.36 Å
- 9B73 chain C against the predicted model P51575: TM-score 0.96, RMSD 1.36 Å
- 9C2C chain C against the predicted model P51575: TM-score 0.96, RMSD 1.34 Å
Elsewhere
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