Research workbench
AlphaFold monomer V2.0 prediction for nucleotide triphosphate diphosphatase NUDT15 (Q9NV35)
Analyse AlphaFold monomer V2.0 prediction for nucleotide triphosphate diphosphatase… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- Accession
- Q9NV35
- Type
- protein
- Length
- 164 residues
- Chains
- 1
- Collection
- MolNFT v1 / AlphaFold
- Contract
- 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
- Owner
- 0x7c75F0f7d6d136A2b8D4C6C6e9b3D8a697949DF1
- Molecule
- Nucleotide triphosphate diphosphatase NUDT15
- UniProt
- Q9NV35
- Pockets
- 1 · best druggability 0.63
Structure
1 distinct chain · 20% helix, 35% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Nucleotide triphosphate diphosphatase NUDT15 | protein | 164 | 20% helix, 35% strand | Q9NV35 |
Pockets
1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 179 | 0.63 | 0.84 | 28 | empty |
Compared structures
- 7B66 · Structure of NUDT15 R139H Mutant in complex with TH7755 · an experimental structure of the same protein · chain A against A, TM-score 0.94
- 7B66 · Structure of NUDT15 R139H mutant in complex with TH7755 · an experimental structure of the same protein · chain A against A, TM-score 0.94
- 5LPG · Structure of NUDT15 in complex with 6-thio-GMP · an experimental structure of the same protein · chain A against A, TM-score 0.94
- 5LPG · Structure of NUDT15 in complex with 6-thio-gmp · an experimental structure of the same protein · chain A against A, TM-score 0.94
- 7B67 · Structure of NUDT15 V18_V19INSGV mutant in complex with TH7755 · an experimental structure of the same protein · chain A against B, TM-score 0.94
- 7B67 · Structure of NUDT15 V18_V19insGV Mutant in complex with TH7755 · an experimental structure of the same protein · chain A against B, TM-score 0.94
- 5BON · Crystal structure of human Nudt15 (MTH2) · an experimental structure of the same protein · chain A against A, TM-score 0.94
- 5BON · Crystal structure of human NUDT15 (MTH2) · an experimental structure of the same protein · chain A against A, TM-score 0.94
- 7B7V · Structure of NUDT15 in complex with acyclovir monophosphate · an experimental structure of the same protein · chain A against B, TM-score 0.93
- 7B7V · Structure of NUDT15 in complex with Acyclovir monophosphate · an experimental structure of the same protein · chain A against B, TM-score 0.93
- 7B63 · Structure of NUDT15 in complex with TH7755 · an experimental structure of the same protein · chain A against A, TM-score 0.93
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9NV35
- Elsewhere: UniProt Q9NV35 · AlphaFold DB Q9NV35
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