MolNFT v2 · #175741 · protein
Structure of NUDT15 R139H Mutant in complex with TH7755
7B66: “Structure of NUDT15 R139H Mutant in complex with TH7755”. X-ray diffraction at 1.6, 1 ligand (SYW). MolNFT v2 #175741 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 7B66
- Type
- protein
- Length
- 628 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v2 / PDB Bank
- Contract
- 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
- Owner
- 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
- Resolution
- 1.6
- Source
- Homo sapiens
- UniProt
- Q9NV35
- Ligands
- SYW
Structure
x-ray diffraction · resolution 1.6 · 4 distinct chains.
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | — | protein | 161 | — | Q9NV35 |
| B | — | protein | 155 | — | Q9NV35 |
| C | — | protein | 156 | — | Q9NV35 |
| D | — | protein | 156 | — | Q9NV35 |
Ligands and binding sites
- SYW · (R)-6-((2-methyl-4-(1-methyl-1H-indole-5-carbonyl) piperazin-1-yl)sulfonyl)benzo[d]oxazol-2(3H)-one · ligand · 4 copies · chains A, B, C, D
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Compared structures
- 7B66 · Structure of NUDT15 R139H mutant in complex with TH7755 · the same entry in another collection · chain D against D, TM-score 1.00
- Q9NV35 · AlphaFold monomer V2.0 prediction for nucleotide triphosphate diphosphatase NUDT15… · a predicted model of the same protein · chain B against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9NV35
- Elsewhere: RCSB PDB 7B66 · PDBe 7B66 · UniProt Q9NV35
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