Research workbench
AlphaFold monomer V2.0 prediction for BDNF/NT-3 growth factors receptor (Q16620)
Analyse AlphaFold monomer V2.0 prediction for BDNF/NT-3 growth factors receptor (Q16620) in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- Accession
- Q16620
- Type
- protein
- Length
- 822 residues
- Chains
- 1
- Collection
- MolNFT v1 / AlphaFold
- Contract
- 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
- Owner
- 0xd1A2963012bEcbC7A8f505464439Ab678C48936f
- Molecule
- BDNF/NT-3 growth factors receptor
- UniProt
- Q16620
- Pockets
- 13 · best druggability 0.68
Structure
1 distinct chain · 22% helix, 25% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | BDNF/NT-3 growth factors receptor | protein | 822 | 22% helix, 25% strand | Q16620 |
Pockets
13 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 56 | 0.68 | 0.95 | 17 | empty |
| 2 | 71 | 0.66 | 0.93 | 20 | empty |
| 3 | 209 | 0.56 | 0.79 | 24 | empty |
| 4 | 152 | 0.56 | 0.81 | 25 | empty |
| 5 | 177 | 0.49 | 0.77 | 25 | empty |
Modifications
Observed in the structure: 6 disulfide (disulfide).
Compared structures
- 4AT5 · Crystal structure of trkb kinase domain in complex with GW2580 · an experimental structure of the same protein · chain A against A, TM-score 0.34
- 4AT5 · Crystal structure of trkb kinase domain in complex with GW2580 · an experimental structure of the same protein · chain A against A, TM-score 0.34
- 4AT4 · Crystal structure of trkb kinase domain in complex with EX429 · an experimental structure of the same protein · chain A against A, TM-score 0.34
- 4AT4 · Crystal structure of trkb kinase domain in complex with EX429 · an experimental structure of the same protein · chain A against A, TM-score 0.34
- 4AT3 · Crystal structure of trkb kinase domain in complex with CPD5N · an experimental structure of the same protein · chain A against A, TM-score 0.33
- 4AT3 · Crystal structure of trkb kinase domain in complex with CPD5N · an experimental structure of the same protein · chain A against A, TM-score 0.33
- 4ASZ · Crystal structure of apo trkb kinase domain · an experimental structure of the same protein · chain A against A, TM-score 0.33
- 4ASZ · Crystal structure of apo TrkB kinase domain · an experimental structure of the same protein · chain A against A, TM-score 0.33
- 1HCF · Crystal structure of trkb-D5 bound to neurotrophin-4/5 · an experimental structure of the same protein · chain A against X, TM-score 0.12
- 1HCF · Crystal structure of TrkB-d5 bound to neurotrophin-4/5 · an experimental structure of the same protein · chain A against X, TM-score 0.12
- 5MO9 · Structure of human TrkB receptor ligand binding domain in complex with the Fab frgment of… · an experimental structure of the same protein · chain A against X, TM-score 0.12
- 5MO9 · Structure of human trkb receptor ligand binding domain in complex with the Fab frgment of… · an experimental structure of the same protein · chain A against X, TM-score 0.12
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q16620
- Elsewhere: UniProt Q16620 · AlphaFold DB Q16620
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