Research workbench
AlphaFold monomer V2.0 prediction for neurexin-1 (Q28146)
Analyse AlphaFold monomer V2.0 prediction for neurexin-1 (Q28146) in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- Accession
- Q28146
- Type
- protein
- Length
- 1,530 residues
- Chains
- 1
- Collection
- MolNFT v1 / AlphaFold
- Contract
- 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
- Owner
- 0x15040d7Bef412593c17C9A4149604C9C2A4788C7
- Molecule
- Neurexin-1
- UniProt
- Q28146
- Pockets
- 10 · best druggability 0.75
Structure
1 distinct chain · 7% helix, 37% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Neurexin-1 | protein | 1530 | 7% helix, 37% strand | Q28146 |
Pockets
10 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1198 | 0.75 | 0.78 | 80 | empty |
| 2 | 109 | 0.50 | 0.81 | 32 | empty |
| 3 | 64 | 0.50 | 0.85 | 19 | empty |
| 4 | 77 | 0.49 | 0.84 | 17 | empty |
| 5 | 190 | 0.44 | 0.74 | 34 | empty |
Modifications
Observed in the structure: 16 disulfide (disulfide).
Compared structures
- 3POY · Crystal structure of the alpha-neurexin-1 ectodomain, lns 2-6 · an experimental structure of the same protein · chain A against A, TM-score 0.65
- 3POY · Crystal Structure of the alpha-Neurexin-1 ectodomain, LNS 2-6 · an experimental structure of the same protein · chain A against A, TM-score 0.65
- 3R05 · Structure of neurexin 1 alpha (domains LNS1-LNS6), with splice insert SS3 · an experimental structure of the same protein · chain A against A, TM-score 0.64
- 3R05 · Structure of neurexin 1 alpha (domains LNS1-LNS6), with splice insert SS3 · an experimental structure of the same protein · chain A against A, TM-score 0.64
- 3QCW · Structure of neurexin 1 alpha (domains LNS1-LNS6), no splice inserts · an experimental structure of the same protein · chain A against A, TM-score 0.64
- 3QCW · Structure of neurexin 1 alpha (domains LNS1-LNS6), no splice inserts · an experimental structure of the same protein · chain A against A, TM-score 0.64
- 3ASI · Alpha-Neurexin-1 ectodomain fragment; LNS5-EGF3-LNS6 · an experimental structure of the same protein · chain A against A, TM-score 0.17
- 3ASI · Alpha-neurexin-1 ectodomain fragment; LNS5-EGF3-LNS6 · an experimental structure of the same protein · chain A against A, TM-score 0.17
- 6CW1 · Crystal structure of Neurexin-1 alpha ectodomain fragment, L2-L3 · an experimental structure of the same protein · chain A against B, TM-score 0.15
- 6CW1 · Crystal structure of neurexin-1 alpha ectodomain fragment, L2-L3 · an experimental structure of the same protein · chain A against B, TM-score 0.15
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q28146
- Elsewhere: UniProt Q28146 · AlphaFold DB Q28146
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