MolNFT v1 · #145706 · protein
Crystal structure of neurexin-1 alpha ectodomain fragment, L2-L3
6CW1: “Crystal structure of neurexin-1 alpha ectodomain fragment, L2-L3”. X-ray diffraction, 3 pockets (best druggability 0.55). MolNFT v1 #145706 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 6CW1
- Type
- protein
- Length
- 762 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Neurexin-1
- UniProt
- Q28146
- Pockets
- 3 · best druggability 0.55
Structure
x-ray diffraction · 2 distinct chains · 7% helix, 46% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Neurexin-1 | protein | 380 | 7% helix, 46% strand | Q28146 |
| B | Neurexin-1 | protein | 382 | 7% helix, 46% strand | Q28146 |
Pockets
3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 118 | 0.55 | 0.83 | 22 | empty |
| 2 | 96 | 0.43 | 0.79 | 28 | empty |
| 3 | 103 | 0.39 | 0.76 | 25 | empty |
Interfaces
1 interface between chains.
- A–B · 798 Ų buried · 15 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 2 disulfide (disulfide).
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q28146
- Elsewhere: RCSB PDB 6CW1 · PDBe 6CW1 · UniProt Q28146
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