Research workbench
AlphaFold monomer V2.0 prediction for NPC1-like intracellular cholesterol transporter 1 (Q6T3U3)
Analyse AlphaFold monomer V2.0 prediction for NPC1-like intracellular cholesterol… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- Accession
- Q6T3U3
- Type
- protein
- Length
- 1,331 residues
- Chains
- 1
- Collection
- MolNFT v1 / AlphaFold
- Contract
- 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
- Owner
- 0x9188600a0FCa2914254C94299b1bd9721Bc4D500
- Molecule
- NPC1-like intracellular cholesterol transporter 1
- UniProt
- Q6T3U3
- Pockets
- 15 · best druggability 0.90
Structure
1 distinct chain · 52% helix, 11% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | NPC1-like intracellular cholesterol transporter 1 | protein | 1331 | 52% helix, 11% strand | Q6T3U3 |
Pockets
15 pockets found on a 1 Å grid, 10 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1196 | 0.90 | 0.91 | 131 | empty |
| 2 | 277 | 0.84 | 0.94 | 41 | empty |
| 3 | 304 | 0.74 | 0.87 | 45 | empty |
| 4 | 57 | 0.71 | 0.97 | 21 | empty |
| 5 | 509 | 0.68 | 0.79 | 41 | empty |
Modifications
Observed in the structure: 15 disulfide (disulfide).
Compared structures
- 6V3H · Structure of NPC1-like intracellular cholesterol transporter 1 (NPC1L1) in complex with… · an experimental structure of the same protein · chain A against A, TM-score 0.90
- 6V3H · Structure of NPC1-like intracellular cholesterol transporter 1 (NPC1L1) in complex with… · an experimental structure of the same protein · chain A against A, TM-score 0.90
- 6V3F · Structure of NPC1-like intracellular cholesterol transporter 1 (NPC1L1) · an experimental structure of the same protein · chain A against A, TM-score 0.77
- 6V3F · Structure of NPC1-like intracellular cholesterol transporter 1 (NPC1L1) · an experimental structure of the same protein · chain A against A, TM-score 0.77
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q6T3U3
- Elsewhere: UniProt Q6T3U3 · AlphaFold DB Q6T3U3
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