UniProt Q6T3U3
NPC1-like intracellular cholesterol transporter 1 (Q6T3U3)
NPC1-like intracellular cholesterol transporter 1 (UniProt Q6T3U3): 4 experimental structures and 1 predicted model on GenesisL1, 4 ligands bound, 43 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- Q6T3U3
- Protein
- NPC1-like intracellular cholesterol transporter 1
- Experimental structures
- 4
- Predicted models
- 1
- Ligands
- 4
- Pockets
- 43 · 3 records with a druggable one
Structures
5 records of Q6T3U3 in the MolNFT archive: 4 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 6V3F | Structure of NPC1-like intracellular cholesterol transporter 1 (NPC1L1) | electron microscopy | A | NAG, CLR | 17 (best 0.87) |
| 6V3F | Structure of NPC1-like intracellular cholesterol transporter 1 (NPC1L1) | electron microscopy | A | NAG, CLR | — |
| 6V3H | Structure of NPC1-like intracellular cholesterol transporter 1 (NPC1L1) in complex with an… | electron microscopy | A | NAG, Y01, QO1 | 11 (best 0.90) |
| 6V3H | Structure of NPC1-like intracellular cholesterol transporter 1 (NPC1L1) in complex with an… | electron microscopy | A | NAG, Y01, QO1 | — |
| Q6T3U3 | AlphaFold monomer V2.0 prediction for NPC1-like intracellular cholesterol transporter 1 (Q6T3U3) | predicted | A | — | 15 (best 0.90) |
Ligands
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · in 4 records
- CLR · Cholesterol · in 2 records
- QO1 · 4-[(2S,3R)-3-[(3S)-3-(4-fluorophenyl)-3-hydroxypropyl]-1-(4-{3-[(methylsulfonyl)amino]prop-1-yn-1-yl}phenyl)-4-oxoazetidin-2-yl]phenyl beta-D-glucopyranosiduronic acid · in 2 records
- Y01 · Cholesterol hemisuccinate · in 2 records
Experiment against prediction
- 6V3H chain A against the predicted model Q6T3U3: TM-score 0.98, RMSD 2.11 Å
- 6V3H chain A against the predicted model Q6T3U3: TM-score 0.98, RMSD 2.11 Å
- 6V3F chain A against the predicted model Q6T3U3: TM-score 0.83, RMSD 5.01 Å
- 6V3F chain A against the predicted model Q6T3U3: TM-score 0.83, RMSD 5.01 Å
Elsewhere
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