Research workbench
AlphaFold monomer V2.0 prediction for npc intracellular sterol transporter 1-related protein 1 (Q12200)
Analyse AlphaFold monomer V2.0 prediction for npc intracellular sterol transporter… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- Accession
- Q12200
- Type
- protein
- Length
- 1,170 residues
- Chains
- 1
- Collection
- MolNFT v1 / AlphaFold
- Contract
- 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
- Owner
- 0x7782F4817b37743d738e9aF842bf74bd50f2015E
- Molecule
- Npc intracellular sterol transporter 1-related protein 1
- UniProt
- Q12200
- Pockets
- 16 · best druggability 0.88
Structure
1 distinct chain · 55% helix, 10% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Npc intracellular sterol transporter 1-related protein 1 | protein | 1170 | 55% helix, 10% strand | Q12200 |
Pockets
16 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1162 | 0.88 | 0.89 | 113 | empty |
| 2 | 817 | 0.77 | 0.81 | 66 | empty |
| 3 | 344 | 0.61 | 0.78 | 38 | empty |
| 4 | 172 | 0.52 | 0.78 | 19 | empty |
| 5 | 110 | 0.49 | 0.81 | 25 | empty |
Modifications
Observed in the structure: 15 disulfide (disulfide).
Compared structures
- 6R4L · Crystal structure of S. cerevisia niemann-pick type C protein NCR1 · an experimental structure of the same protein · chain A against A, TM-score 0.82
- 6R4L · Crystal structure of S. cerevisia Niemann-Pick type C protein NCR1 · an experimental structure of the same protein · chain A against A, TM-score 0.82
- 8QED · S. cerevisia Niemann-Pick type C protein NCR1 in LMNG at pH 5.5 · an experimental structure of the same protein · chain A against A, TM-score 0.80
- 8QEB · S. cerevisia Niemann-Pick type C protein NCR1 in GDN at pH 7.5 · an experimental structure of the same protein · chain A against A, TM-score 0.80
- 8QEC · S. cerevisia Niemann-Pick type C protein NCR1 in GDN at pH 5.5 · an experimental structure of the same protein · chain A against A, TM-score 0.80
- 8QEE · S. cerevisia Niemann-Pick type C protein NCR1 in Peptidisc at pH 7.5 · an experimental structure of the same protein · chain A against A, TM-score 0.70
- 9F41 · Crystal structure of the NTD domain from S. cerevisia Niemann-Pick type C protein NCR1… · an experimental structure of the same protein · chain A against A, TM-score 0.19
- 9F40 · Crystal structure of the NTD domain from S. cerevisia Niemann-Pick type C protein NCR1… · an experimental structure of the same protein · chain A against D, TM-score 0.19
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q12200
- Elsewhere: UniProt Q12200 · AlphaFold DB Q12200
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.