Research workbench

AlphaFold monomer V2.0 prediction for homeobox protein nkx-2.5 (P42582)

Analyse AlphaFold monomer V2.0 prediction for homeobox protein nkx-2.5 (P42582) in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

Accession: P42582
Type: protein
Length: 318 residues
Chains: 1
Collection: MolNFT v1 / AlphaFold
Contract: 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
Owner: 0xBb1c0111cF7574f1Cbe3B25d466dc5822347678f
Molecule: Homeobox protein nkx-2.5
UniProt: P42582
Pockets: 1 · best druggability 0.30

Structure

1 distinct chain · 25% helix, 1% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Homeobox protein nkx-2.5	protein	318	25% helix, 1% strand	P42582

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	76	0.30	0.72	11	empty

Compared structures

5FLV · Crystal structure of NKX2-5 and TBX5 bound to the Nppa promoter region · an experimental structure of the same protein · chain A against I, TM-score 0.22
5FLV · Crystal structure of NKX2-5 and TBX5 bound to the nppa promoter region · an experimental structure of the same protein · chain A against I, TM-score 0.22

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P42582
Elsewhere: UniProt P42582 · AlphaFold DB P42582

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