Research workbench
AlphaFold monomer V2.0 prediction for homeobox protein nkx-2.5 (P52952)
Analyse AlphaFold monomer V2.0 prediction for homeobox protein nkx-2.5 (P52952) in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- Accession
- P52952
- Type
- protein
- Length
- 324 residues
- Chains
- 1
- Collection
- MolNFT v1 / AlphaFold
- Contract
- 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
- Owner
- 0xBF0D2e107Ce1EcD2C4369B042274201DB719AaAF
- Molecule
- Homeobox protein nkx-2.5
- UniProt
- P52952
- Pockets
- 1 · best druggability 0.27
Structure
1 distinct chain · 29% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Homeobox protein nkx-2.5 | protein | 324 | 29% helix, 0% strand | P52952 |
Pockets
1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 55 | 0.27 | 0.74 | 9 | empty |
Compared structures
- 3RKQ · NKX2.5 Homeodomain dimer bound to ANF-242 DNA · an experimental structure of the same protein · chain A against A, TM-score 0.18
- 3RKQ · NKX2.5 homeodomain dimer bound to anf-242 DNA · an experimental structure of the same protein · chain A against A, TM-score 0.18
- 6WC5 · Crystal Structure of a Ternary MEF2B/NKX2-5/myocardin enhancer DNA Complex · an experimental structure of the same protein · chain A against I, TM-score 0.17
- 6WC2 · Crystal structure of a ternary MEF2 CHIMERA/NKX2-5/MYOCARDIN enhancer DNA complex · an experimental structure of the same protein · chain A against M, TM-score 0.17
- 6WC2 · Crystal Structure of a Ternary MEF2 Chimera/NKX2-5/myocardin enhancer DNA Complex · an experimental structure of the same protein · chain A against M, TM-score 0.17
- 4S0H · TBX5 db, NKX2.5 hd, anf DNA complex · an experimental structure of the same protein · chain A against B, TM-score 0.16
- 4S0H · TBX5 DB, NKX2.5 HD, ANF DNA Complex · an experimental structure of the same protein · chain A against B, TM-score 0.16
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P52952
- Elsewhere: UniProt P52952 · AlphaFold DB P52952
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