UniProt P52952
Homeobox protein Nkx-2.5 (P52952)
Homeobox protein Nkx-2.5 (UniProt P52952): 7 experimental structures and 1 predicted model on GenesisL1, 6 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P52952
- Protein
- Homeobox protein Nkx-2.5
- Experimental structures
- 7
- Predicted models
- 1
- Pockets
- 6 · 1 record with a druggable one
Structures
8 records of P52952 in the MolNFT archive: 7 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 3RKQ | NKX2.5 Homeodomain dimer bound to ANF-242 DNA | x-ray diffraction | A, B | — | — |
| 3RKQ | NKX2.5 homeodomain dimer bound to anf-242 DNA | x-ray diffraction | A, B | — | — |
| 4S0H | TBX5 DB, NKX2.5 HD, ANF DNA Complex | x-ray diffraction | B, F | — | — |
| 4S0H | TBX5 db, NKX2.5 hd, anf DNA complex | x-ray diffraction | B, F | — | — |
| 6WC2 | Crystal Structure of a Ternary MEF2 Chimera/NKX2-5/myocardin enhancer DNA Complex | x-ray diffraction | M, N, O | — | — |
| 6WC2 | Crystal structure of a ternary MEF2 CHIMERA/NKX2-5/MYOCARDIN enhancer DNA complex | x-ray diffraction | M, N, O | — | — |
| 6WC5 | Crystal Structure of a Ternary MEF2B/NKX2-5/myocardin enhancer DNA Complex | x-ray diffraction | I, N | — | 5 (best 0.72) |
| P52952 | AlphaFold monomer V2.0 prediction for homeobox protein nkx-2.5 (P52952) | predicted | A | — | 1 (best 0.27) |
Experiment against prediction
- 6WC2 chain O against the predicted model P52952: TM-score 0.98, RMSD 0.37 Å
- 6WC2 chain O against the predicted model P52952: TM-score 0.98, RMSD 0.37 Å
- 6WC2 chain M against the predicted model P52952: TM-score 0.97, RMSD 0.48 Å
- 6WC2 chain M against the predicted model P52952: TM-score 0.97, RMSD 0.48 Å
- 6WC2 chain N against the predicted model P52952: TM-score 0.97, RMSD 0.57 Å
- 6WC2 chain N against the predicted model P52952: TM-score 0.97, RMSD 0.57 Å
- 6WC5 chain I against the predicted model P52952: TM-score 0.97, RMSD 0.48 Å
- 4S0H chain B against the predicted model P52952: TM-score 0.96, RMSD 0.50 Å
- 4S0H chain B against the predicted model P52952: TM-score 0.96, RMSD 0.50 Å
- 6WC5 chain N against the predicted model P52952: TM-score 0.94, RMSD 0.66 Å
Elsewhere
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