Research workbench
AlphaFold monomer V2.0 prediction for nuclear factor nf-kappa-B P100 subunit (Q00653)
Analyse AlphaFold monomer V2.0 prediction for nuclear factor nf-kappa-B P100 subunit… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- Accession
- Q00653
- Type
- protein
- Length
- 900 residues
- Chains
- 1
- Collection
- MolNFT v1 / AlphaFold
- Contract
- 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
- Owner
- 0x5e58272ea25a05e06901A2eAe9f63939b344e0c6
- Molecule
- Nuclear factor nf-kappa-B P100 subunit
- UniProt
- Q00653
- Pockets
- 3 · best druggability 0.55
Structure
1 distinct chain · 31% helix, 12% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Nuclear factor nf-kappa-B P100 subunit | protein | 900 | 31% helix, 12% strand | Q00653 |
Pockets
3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 132 | 0.55 | 0.82 | 22 | empty |
| 2 | 122 | 0.46 | 0.78 | 28 | empty |
| 3 | 50 | 0.38 | 0.81 | 18 | empty |
Compared structures
- 4OT9 · Crystal structure of the C-terminal domain of P100/NF-KB2 · an experimental structure of the same protein · chain A against A, TM-score 0.32
- 4OT9 · crystal structure of the C-terminal domain of p100/NF-kB2 · an experimental structure of the same protein · chain A against A, TM-score 0.32
- 7W7L · Structure of nf-kb P52 homodimer bound to 13-mer A/T-centric P- selectin kb DNA fragment · an experimental structure of the same protein · chain A against A, TM-score 0.32
- 3DO7 · X-ray structure of a nf-kb P52/RELB/DNA complex · an experimental structure of the same protein · chain A against B, TM-score 0.32
- 3DO7 · X-ray structure of a NF-kB p52/RelB/DNA complex · an experimental structure of the same protein · chain A against B, TM-score 0.32
- 7VUP · Structure of nf-kb P52 homodimer bound to +1/-1 swap P-selectin kb DNA fragment · an experimental structure of the same protein · chain A against A, TM-score 0.31
- 1A3Q · Human nf-kappa-B P52 bound to DNA · an experimental structure of the same protein · chain A against A, TM-score 0.31
- 1A3Q · Human nf-kappa-B P52 bound to DNA · an experimental structure of the same protein · chain A against A, TM-score 0.31
- 7VUQ · Structure of nf-kb P52 homodimer bound to A/T-centric P-selectin kb DNA fragment · an experimental structure of the same protein · chain A against B, TM-score 0.31
- 7CLI · Structure of NF-kB p52 homodimer bound to P-Selectin kB DNA fragment · an experimental structure of the same protein · chain A against B, TM-score 0.31
- 7CLI · Structure of nf-kb P52 homodimer bound to P-selectin kb DNA fragment · an experimental structure of the same protein · chain A against B, TM-score 0.31
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q00653
- Elsewhere: UniProt Q00653 · AlphaFold DB Q00653
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