UniProt Q00653
Nuclear factor NF-kappa-B p100 subunit (Q00653)
Nuclear factor NF-kappa-B p100 subunit (UniProt Q00653): 15 experimental structures and 1 predicted model on GenesisL1, 5 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q00653
- Protein
- Nuclear factor NF-kappa-B p100 subunit
- Experimental structures
- 15
- Predicted models
- 1
- Pockets
- 5 · 2 records with a druggable one
Structures
16 records of Q00653 in the MolNFT archive: 15 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1A3Q | Human nf-kappa-B P52 bound to DNA | x-ray diffraction | A, B | — | — |
| 1A3Q | Human nf-kappa-B P52 bound to DNA | x-ray diffraction | A, B | — | — |
| 2D96 | Solution structure of the Death domain of Nuclear factor NF-kappa-B p100 | solution nmr | A | — | — |
| 2D96 | Solution structure of the death domain of nuclear factor nf-kappa-B P100 | solution nmr | A | — | — |
| 3DO7 | X-ray structure of a NF-kB p52/RelB/DNA complex | x-ray diffraction | B | — | — |
| 3DO7 | X-ray structure of a nf-kb P52/RELB/DNA complex | x-ray diffraction | B | — | — |
| 4OT9 | crystal structure of the C-terminal domain of p100/NF-kB2 | x-ray diffraction | A | — | — |
| 4OT9 | Crystal structure of the C-terminal domain of P100/NF-KB2 | x-ray diffraction | A | — | — |
| 5ZMC | Structural Basis for Reactivation of -146C>T Mutant TERT Promoter by cooperative binding of p52 and… | x-ray diffraction | A | — | 2 (best 0.62) |
| 5ZMC | Structural basis for reactivation of -146C>T mutant tert promoter by cooperative binding of P52 and… | x-ray diffraction | A | — | — |
| 7CLI | Structure of NF-kB p52 homodimer bound to P-Selectin kB DNA fragment | x-ray diffraction | A, B | — | — |
| 7CLI | Structure of nf-kb P52 homodimer bound to P-selectin kb DNA fragment | x-ray diffraction | A, B | — | — |
| 7VUP | Structure of nf-kb P52 homodimer bound to +1/-1 swap P-selectin kb DNA fragment | x-ray diffraction | A, B | — | — |
| 7VUQ | Structure of nf-kb P52 homodimer bound to A/T-centric P-selectin kb DNA fragment | x-ray diffraction | B, A | — | — |
| 7W7L | Structure of nf-kb P52 homodimer bound to 13-mer A/T-centric P- selectin kb DNA fragment | x-ray diffraction | A, B | — | — |
| Q00653 | AlphaFold monomer V2.0 prediction for nuclear factor nf-kappa-B P100 subunit (Q00653) | predicted | A | — | 3 (best 0.55) |
Experiment against prediction
- 5ZMC chain A against the predicted model Q00653: TM-score 0.97, RMSD 0.68 Å
- 5ZMC chain A against the predicted model Q00653: TM-score 0.97, RMSD 0.68 Å
- 1A3Q chain A against the predicted model Q00653: TM-score 0.97, RMSD 1.17 Å
- 1A3Q chain A against the predicted model Q00653: TM-score 0.97, RMSD 1.17 Å
- 3DO7 chain B against the predicted model Q00653: TM-score 0.96, RMSD 1.40 Å
- 3DO7 chain B against the predicted model Q00653: TM-score 0.96, RMSD 1.40 Å
- 7W7L chain A against the predicted model Q00653: TM-score 0.96, RMSD 1.49 Å
- 7W7L chain B against the predicted model Q00653: TM-score 0.95, RMSD 1.45 Å
- 4OT9 chain A against the predicted model Q00653: TM-score 0.95, RMSD 1.61 Å
- 4OT9 chain A against the predicted model Q00653: TM-score 0.95, RMSD 1.61 Å
Elsewhere
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