Research workbench
AlphaFold monomer V2.0 prediction for E3 ubiquitin-protein ligase NEDD4 (Q62940)
Analyse AlphaFold monomer V2.0 prediction for E3 ubiquitin-protein ligase NEDD4 (Q62940) in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- Accession
- Q62940
- Type
- protein
- Length
- 887 residues
- Chains
- 1
- Collection
- MolNFT v1 / AlphaFold
- Contract
- 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
- Owner
- 0xc0F878C3f3E2a1874e2A6daC80d429e553DdB0D5
- Molecule
- E3 ubiquitin-protein ligase NEDD4
- UniProt
- Q62940
- Pockets
- 11 · best druggability 0.77
Structure
1 distinct chain · 26% helix, 18% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | E3 ubiquitin-protein ligase NEDD4 | protein | 887 | 26% helix, 18% strand | Q62940 |
Pockets
11 pockets found on a 1 Å grid, 6 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 749 | 0.77 | 0.81 | 98 | empty |
| 2 | 121 | 0.71 | 0.92 | 31 | empty |
| 3 | 344 | 0.57 | 0.76 | 39 | empty |
| 4 | 97 | 0.56 | 0.85 | 18 | empty |
| 5 | 236 | 0.52 | 0.76 | 26 | empty |
Compared structures
- 1I5H · Solution structure of the RNEDD4 wwiii domain-renal BP2 peptide complex · an experimental structure of the same protein · chain A against W, TM-score 0.05
- 1I5H · Solution structure of the RNEDD4 wwiii domain-renal BP2 peptide complex · an experimental structure of the same protein · chain A against W, TM-score 0.05
- 2N8U · Solution structure of the RNEDD4 WW2 domain by NMR · an experimental structure of the same protein · chain A against A, TM-score 0.04
- 2N8U · Solution Structure of the rNedd4 WW2 Domain by NMR · an experimental structure of the same protein · chain A against A, TM-score 0.04
- 2N8S · Solution Structure of the rNedd4 WW1 Domain by NMR · an experimental structure of the same protein · chain A against A, TM-score 0.04
- 2N8S · Solution structure of the RNEDD4 WW1 domain by NMR · an experimental structure of the same protein · chain A against A, TM-score 0.04
- 2N8T · Solution structure of the RNEDD4 WW2 domain-CX43CT peptide complex by NMR · an experimental structure of the same protein · chain A against A, TM-score 0.04
- 2N8T · Solution Structure of the rNedd4 WW2 Domain-Cx43CT Peptide Complex by NMR · an experimental structure of the same protein · chain A against A, TM-score 0.04
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q62940
- Elsewhere: UniProt Q62940 · AlphaFold DB Q62940
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