MolNFT v1 · #45632 · protein

Solution structure of the RNEDD4 WW2 domain-CX43CT peptide complex by NMR

2N8T · E3 ubiquitin-protein ligase NEDD4: “Solution structure of the RNEDD4 WW2 domain-CX43CT peptide complex by NMR”. Solution nmr. MolNFT v1 #45632 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 2N8T
Type: protein
Length: 53 residues
Chains: 2
Method: solution nmr
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: E3 ubiquitin-protein ligase NEDD4; CX43CT peptide
EC: 6.3.2.-
UniProt: Q62940, P08050

Structure

solution nmr · 2 distinct chains · 0% helix, 26% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	E3 ubiquitin-protein ligase NEDD4 (EC 6.3.2.-)	protein	39	0% helix, 31% strand	Q62940
B	CX43CT peptide	protein	14	0% helix, 14% strand	P08050

Interfaces

1 interface between chains.

A–B · 538 Å² buried · 2 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 2 modified (phosphorylation).

Compared structures

2N8T · Solution Structure of the rNedd4 WW2 Domain-Cx43CT Peptide Complex by NMR · the same entry in another collection · chain A against A, TM-score 1.00
Q62940 · AlphaFold monomer V2.0 prediction for E3 ubiquitin-protein ligase NEDD4 (Q62940) · a predicted model of the same protein · chain A against A, TM-score 0.66
P08050 · AlphaFold monomer V2.0 prediction for gap junction alpha-1 protein (P08050) · a predicted model of the same protein · chain B against A, TM-score 0.26

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q62940
Every structure of UniProt P08050
Elsewhere: RCSB PDB 2N8T · PDBe 2N8T · UniProt Q62940 · UniProt P08050

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