Research workbench
AlphaFold monomer V2.0 prediction for E3 ubiquitin-protein ligase NEDD4-like (Q96PU5)
Analyse AlphaFold monomer V2.0 prediction for E3 ubiquitin-protein ligase NEDD4-like… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- Accession
- Q96PU5
- Type
- protein
- Length
- 975 residues
- Chains
- 1
- Collection
- MolNFT v1 / AlphaFold
- Contract
- 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
- Owner
- 0x0944786f8d97650C95AfEbF84205C238dB68d6b1
- Molecule
- E3 ubiquitin-protein ligase NEDD4-like
- UniProt
- Q96PU5
- Pockets
- 8 · best druggability 0.70
Structure
1 distinct chain · 24% helix, 18% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | E3 ubiquitin-protein ligase NEDD4-like | protein | 975 | 24% helix, 18% strand | Q96PU5 |
Pockets
8 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 305 | 0.70 | 0.84 | 39 | empty |
| 2 | 377 | 0.66 | 0.80 | 34 | empty |
| 3 | 216 | 0.55 | 0.78 | 26 | empty |
| 4 | 216 | 0.49 | 0.75 | 38 | empty |
| 5 | 93 | 0.49 | 0.82 | 17 | empty |
Compared structures
- 5HPK · System-wide modulation of hect E3 ligases with selective ubiquitin variant probes: NEDD4L… · an experimental structure of the same protein · chain A against A, TM-score 0.28
- 5HPK · System-wide modulation of HECT E3 ligases with selective ubiquitin variant probes: NEDD4L… · an experimental structure of the same protein · chain A against A, TM-score 0.28
- 2ONI · Catalytic Domain of the Human NEDD4-like E3 Ligase · an experimental structure of the same protein · chain A against A, TM-score 0.27
- 2ONI · Catalytic domain of the human NEDD4-like E3 ligase · an experimental structure of the same protein · chain A against A, TM-score 0.27
- 3JVZ · E2~UBIQUITIN-hect · an experimental structure of the same protein · chain A against C, TM-score 0.27
- 3JVZ · E2~Ubiquitin-HECT · an experimental structure of the same protein · chain A against C, TM-score 0.27
- 3JW0 · E2~UBIQUITIN-hect · an experimental structure of the same protein · chain A against C, TM-score 0.27
- 3JW0 · E2~Ubiquitin-HECT · an experimental structure of the same protein · chain A against C, TM-score 0.27
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q96PU5
- Elsewhere: UniProt Q96PU5 · AlphaFold DB Q96PU5
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