UniProt Q96PU5
E3 ubiquitin-protein ligase NEDD4-like (Q96PU5)
E3 ubiquitin-protein ligase NEDD4-like (UniProt Q96PU5), EC 2.3.2.26: 31 experimental structures and 1 predicted model on GenesisL1, 2 ligands bound, 31 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- Q96PU5
- Protein
- E3 ubiquitin-protein ligase NEDD4-like
- EC
- 2.3.2.26
- Experimental structures
- 31
- Predicted models
- 1
- Ligands
- 2
- Pockets
- 31 · 4 records with a druggable one
Structures
32 records of Q96PU5 in the MolNFT archive: 31 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2LAJ | Third WW domain of human Nedd4L in complex with doubly phosphorylated human smad3 derived peptide | solution nmr | A | — | — |
| 2LAJ | Third ww domain of human NEDD4L in complex with doubly phosphorylated human SMAD3 derived peptide | solution nmr | A | — | — |
| 2LB2 | Structure of the second domain of human Nedd4L in complex with a phosphorylated pTPY motif derived… | solution nmr | A | — | — |
| 2LB2 | Structure of the second domain of human NEDD4L in complex with a phosphorylated ptpy motif derived… | solution nmr | A | — | — |
| 2LTY | NEDD4L WW2 domain in complex with a Smad7 derived peptide | solution nmr | A | — | — |
| 2LTY | NEDD4L WW2 domain in complex with a SMAD7 derived peptide | solution nmr | A | — | — |
| 2MPT | WW3 domain of Nedd4L in complex with its HECT domain PY motif | solution nmr | A, B | — | — |
| 2MPT | WW3 domain of NEDD4L in complex with its hect domain py motif | solution nmr | A, B | — | — |
| 2NSQ | Crystal structure of the C2 domain of the human E3 ubiquitin-protein ligase NEDD4-like protein | x-ray diffraction | A | — | — |
| 2NSQ | Crystal structure of the C2 domain of the human E3 ubiquitin-protein ligase NEDD4-like protein | x-ray diffraction | A | — | — |
| 2ONI | Catalytic Domain of the Human NEDD4-like E3 Ligase | x-ray diffraction | A | — | — |
| 2ONI | Catalytic domain of the human NEDD4-like E3 ligase | x-ray diffraction | A | — | — |
| 3JVZ | E2~Ubiquitin-HECT | x-ray diffraction | C, D | — | — |
| 3JVZ | E2~UBIQUITIN-hect | x-ray diffraction | C, D | — | — |
| 3JW0 | E2~Ubiquitin-HECT | x-ray diffraction | C, D | — | — |
| 3JW0 | E2~UBIQUITIN-hect | x-ray diffraction | C, D | — | — |
| 5HPK | System-wide modulation of HECT E3 ligases with selective ubiquitin variant probes: NEDD4L and UbV… | x-ray diffraction | A | — | — |
| 5HPK | System-wide modulation of hect E3 ligases with selective ubiquitin variant probes: NEDD4L and ubv… | x-ray diffraction | A | — | — |
| 6ZBT | Structure of 14-3-3 gamma in complex with Nedd4-2 14-3-3 binding motif Ser342 | x-ray diffraction | E, F, G, H | — | 9 (best 0.68) |
| 6ZBT | Structure of 14-3-3 gamma in complex with NEDD4-2 14-3-3 binding motif SER342 | x-ray diffraction | E, F, G, H | — | — |
| 6ZC9 | Structure of 14-3-3 gamma in complex with Nedd4-2 14-3-3 binding motif Ser448 | x-ray diffraction | E, F, G, H | — | 10 (best 0.69) |
| 6ZC9 | Structure of 14-3-3 gamma in complex with NEDD4-2 14-3-3 binding motif SER448 | x-ray diffraction | E, F, G, H | — | — |
| 7LP1 | Structure of Nedd4L WW3 domain | x-ray diffraction | A | NO3 | — |
| 7LP1 | Structure of NEDD4L WW3 domain | x-ray diffraction | A | NO3 | — |
| 7LP3 | Structure of Nedd4L WW3 domain | x-ray diffraction | A, C | SO4 | — |
| 7LP3 | Structure of NEDD4L WW3 domain | x-ray diffraction | A, C | SO4 | — |
| 7LP4 | Structure of Nedd4L WW3 domain | solution nmr | A | — | 1 (best 0.34) |
| 7LP4 | Structure of NEDD4L WW3 domain | solution nmr | A | — | — |
| 7LP5 | Structure of Nedd4L WW3 domain | solution nmr | A | — | — |
| 7LP5 | Structure of NEDD4L WW3 domain | solution nmr | A | — | — |
| 7NMZ | Structure of 14-3-3 eta in complex with Nedd4-2(335-455) containing two 14-3-3 binding motifs… | x-ray diffraction | C | — | 3 (best 0.65) |
| Q96PU5 | AlphaFold monomer V2.0 prediction for E3 ubiquitin-protein ligase NEDD4-like (Q96PU5) | predicted | A | — | 8 (best 0.70) |
Ligands
Experiment against prediction
- 6ZC9 chain F against the predicted model Q96PU5: TM-score 0.94, RMSD 0.12 Å
- 6ZC9 chain F against the predicted model Q96PU5: TM-score 0.94, RMSD 0.12 Å
- 2NSQ chain A against the predicted model Q96PU5: TM-score 0.94, RMSD 1.52 Å
- 2NSQ chain A against the predicted model Q96PU5: TM-score 0.94, RMSD 1.52 Å
- 6ZC9 chain G against the predicted model Q96PU5: TM-score 0.89, RMSD 0.18 Å
- 7LP3 chain C against the predicted model Q96PU5: TM-score 0.85, RMSD 1.15 Å
- 7LP3 chain A against the predicted model Q96PU5: TM-score 0.85, RMSD 1.17 Å
- 7LP3 chain A against the predicted model Q96PU5: TM-score 0.85, RMSD 1.17 Å
- 7LP1 chain A against the predicted model Q96PU5: TM-score 0.81, RMSD 2.00 Å
- 7LP1 chain A against the predicted model Q96PU5: TM-score 0.81, RMSD 2.00 Å
Elsewhere
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