Research workbench
AlphaFold monomer V2.0 prediction for nuclear receptor corepressor 2 (Q9Y618)
Analyse AlphaFold monomer V2.0 prediction for nuclear receptor corepressor 2 (Q9Y618) in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- Accession
- Q9Y618
- Type
- protein
- Length
- 2,514 residues
- Chains
- 1
- Collection
- MolNFT v1 / AlphaFold
- Contract
- 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
- Owner
- 0x3ec41f9b413220A375Ef4910666Ef7e01d098239
- Molecule
- Nuclear receptor corepressor 2
- UniProt
- Q9Y618
- Pockets
- 5 · best druggability 0.52
Structure
1 distinct chain · 13% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Nuclear receptor corepressor 2 | protein | 2514 | 13% helix, 0% strand | Q9Y618 |
Pockets
5 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 105 | 0.52 | 0.82 | 14 | empty |
| 2 | 112 | 0.35 | 0.73 | 19 | empty |
| 3 | 61 | 0.30 | 0.75 | 12 | empty |
| 4 | 66 | 0.27 | 0.73 | 9 | empty |
| 5 | 52 | 0.25 | 0.73 | 11 | empty |
Compared structures
- 2LTP · Solution structure of the SANT2 domain of the human nuclear receptor corepressor 2… · an experimental structure of the same protein · chain A against A, TM-score 0.03
- 2LTP · Solution structure of the SANT2 domain of the human nuclear receptor corepressor 2… · an experimental structure of the same protein · chain A against A, TM-score 0.03
- 4A69 · Structure of HDAC3 bound to corepressor and inositol tetraphosphate · an experimental structure of the same protein · chain A against C, TM-score 0.03
- 4A69 · Structure of HDAC3 bound to corepressor and inositol tetraphosphate · an experimental structure of the same protein · chain A against C, TM-score 0.03
- 1XC5 · Solution Structure of the SMRT Deacetylase Activation Domain · an experimental structure of the same protein · chain A against A, TM-score 0.02
- 1XC5 · Solution structure of the smrt deacetylase activation domain · an experimental structure of the same protein · chain A against A, TM-score 0.02
- 8AQN · Crystal structure of PPARG and NCOR2 with BAY-4931, an inverse agonist (compound 6c) · an experimental structure of the same protein · chain A against C, TM-score 0.01
- 3R29 · Crystal structure of rxralpha ligand-binding domain complexed with corepressor SMRT2 · an experimental structure of the same protein · chain A against C, TM-score 0.01
- 3R29 · Crystal structure of RXRalpha ligand-binding domain complexed with corepressor SMRT2 · an experimental structure of the same protein · chain A against C, TM-score 0.01
- 1R2B · Crystal structure of the BCL6 btb domain complexed with a smrt co- repressor peptide · an experimental structure of the same protein · chain A against C, TM-score 0.01
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9Y618
- Elsewhere: UniProt Q9Y618 · AlphaFold DB Q9Y618
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