AlphaFold monomer V2.0 prediction for udp-N-acetylmuramoylalanine-- D-glutamate ligase (P14900)

Structure

1 distinct chain · 33% helix, 22% strand (DSSP).

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Compared structures

• 2X5O · Discovery of Novel 5-Benzylidenerhodanine- and 5-Benzylidene- thiazolidine-2,4-dione… · an experimental structure of the same protein · chain A against A, TM-score 0.97
• 2X5O · Discovery of novel 5-benzylidenerhodanine- and 5-benzylidene- thiazolidine-2,4-dione… · an experimental structure of the same protein · chain A against A, TM-score 0.97
• 2Y68 · Structure-based design of a new series of D-glutamic acid-based inhibitors of bacterial… · an experimental structure of the same protein · chain A against A, TM-score 0.96
• 2Y68 · Structure-based design of a new series of D-glutamic acid-based inhibitors of bacterial… · an experimental structure of the same protein · chain A against A, TM-score 0.96
• 2WJP · Crystal structure of murd ligase in complex with D-glu containing rhodanine inhibitor · an experimental structure of the same protein · chain A against A, TM-score 0.96
• 2WJP · Crystal structure of murd ligase in complex with D-glu containing rhodanine inhibitor · an experimental structure of the same protein · chain A against A, TM-score 0.96
• 2UUP · Crystal structure of MurD ligase in complex with D-Glu containing sulfonamide inhibitor · an experimental structure of the same protein · chain A against A, TM-score 0.96
• 2UUP · Crystal structure of murd ligase in complex with D-glu containing sulfonamide inhibitor · an experimental structure of the same protein · chain A against A, TM-score 0.96
• 2Y1O · Dual-target inhibitor of murd and mure ligases: design, synthesis and binding mode studies · an experimental structure of the same protein · chain A against A, TM-score 0.96
• 2Y1O · Dual-target Inhibitor of MurD and MurE Ligases: Design, Synthesis and Binding Mode Studies · an experimental structure of the same protein · chain A against A, TM-score 0.96
• 2Y66 · New 5-Benzylidenethiazolidine-4-one Inhibitors of Bacterial MurD Ligase: Design… · an experimental structure of the same protein · chain A against A, TM-score 0.96
• 2Y66 · New 5-benzylidenethiazolidine-4-one inhibitors of bacterial murd ligase: design… · an experimental structure of the same protein · chain A against A, TM-score 0.96

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt P14900
• Elsewhere: UniProt P14900 · AlphaFold DB P14900