Research workbench
AlphaFold monomer V2.0 prediction for mas-related G-protein coupled receptor member X4 (Q96LA9)
Analyse AlphaFold monomer V2.0 prediction for mas-related G-protein coupled receptor… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- Accession
- Q96LA9
- Type
- protein
- Length
- 322 residues
- Chains
- 1
- Collection
- MolNFT v1 / AlphaFold
- Contract
- 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
- Owner
- 0x41f982d1Ab404B1F39f5162365b91bF104CE6a14
- Molecule
- Mas-related G-protein coupled receptor member X4
- UniProt
- Q96LA9
- Pockets
- 4 · best druggability 0.71
Structure
1 distinct chain · 71% helix, 1% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Mas-related G-protein coupled receptor member X4 | protein | 322 | 71% helix, 1% strand | Q96LA9 |
Pockets
4 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 494 | 0.71 | 0.80 | 45 | empty |
| 2 | 57 | 0.43 | 0.82 | 15 | empty |
| 3 | 78 | 0.36 | 0.75 | 14 | empty |
| 4 | 73 | 0.33 | 0.75 | 12 | empty |
Modifications
Observed in the structure: 2 disulfide (disulfide).
Compared structures
- 8K4S · CryoEM structure of Gq coupled MRGPRX4 with agonist DCA-3P · an experimental structure of the same protein · chain A against E, TM-score 0.69
- 8KEX · CryoEM structure of Gq coupled MRGPRX4 with agonist DCA-3P, local · an experimental structure of the same protein · chain A against E, TM-score 0.69
- 7S8P · CryoEM structure of Gq-coupled MRGPRX4 with small molecule agonist MS47134 · an experimental structure of the same protein · chain A against R, TM-score 0.69
- 7S8P · Cryoem structure of gq-coupled MRGPRX4 with small molecule agonist MS47134 · an experimental structure of the same protein · chain A against R, TM-score 0.69
- 8YRG · CryoEM structure of fospropofol-bound MRGPRX4-Gq complex · an experimental structure of the same protein · chain A against R, TM-score 0.67
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q96LA9
- Elsewhere: UniProt Q96LA9 · AlphaFold DB Q96LA9
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