UniProt Q96LA9
Soluble cytochrome b562,Mas-related G-protein coupled receptor member X4,Green fluorescent protein (Q96LA9)
Soluble cytochrome b562,Mas-related G-protein coupled receptor member X4,Green fluorescent protein (UniProt Q96LA9): 5 experimental structures and 1 predicted model on GenesisL1, 3 ligands bound, 22 pockets. Binding sites…
- UniProt
- Q96LA9
- Protein
- Soluble cytochrome b562,Mas-related G-protein coupled receptor member X4,Green…
- Experimental structures
- 5
- Predicted models
- 1
- Ligands
- 3
- Pockets
- 22 · 5 records with a druggable one
Structures
6 records of Q96LA9 in the MolNFT archive: 5 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 7S8P | CryoEM structure of Gq-coupled MRGPRX4 with small molecule agonist MS47134 | electron microscopy | R | 8IX | 4 (best 0.68) |
| 7S8P | Cryoem structure of gq-coupled MRGPRX4 with small molecule agonist MS47134 | electron microscopy | R | 8IX | — |
| 8K4S | CryoEM structure of Gq coupled MRGPRX4 with agonist DCA-3P | electron microscopy | E | JW0 | 4 (best 0.77) |
| 8KEX | CryoEM structure of Gq coupled MRGPRX4 with agonist DCA-3P, local | electron microscopy | E | JW0 | 3 (best 0.76) |
| 8YRG | CryoEM structure of fospropofol-bound MRGPRX4-Gq complex | electron microscopy | R | A1LZU | 7 (best 0.67) |
| Q96LA9 | AlphaFold monomer V2.0 prediction for mas-related G-protein coupled receptor member X4 (Q96LA9) | predicted | A | — | 4 (best 0.71) |
Ligands
- 8IX · N-[(1R,3R,5S,7R)-3,5-dimethyltricyclo[3.3.1.1~3, 7~]decane-1-carbonyl]-D-phenylalanine · in 2 records
- JW0 · (4~{R})-4-[(3~{R},5~{R},8~{R},9~{S},10~{S},12~{S},13~{R},14~{S},17~{R})-10,13-dimethyl-12-oxidanyl-3-phosphonooxy-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1~{H}-cyclopenta[a]phenanthren-17-yl]pentanoic acid · in 2 records
- A1LZU · [2,6-di(propan-2-yl)phenoxy]methyl dihydrogen phosphate · in 1 record
Experiment against prediction
- 8YRG chain R against the predicted model Q96LA9: TM-score 0.90, RMSD 2.26 Å
- 7S8P chain R against the predicted model Q96LA9: TM-score 0.88, RMSD 2.52 Å
- 7S8P chain R against the predicted model Q96LA9: TM-score 0.88, RMSD 2.52 Å
- 8K4S chain E against the predicted model Q96LA9: TM-score 0.86, RMSD 2.77 Å
- 8KEX chain E against the predicted model Q96LA9: TM-score 0.86, RMSD 2.76 Å
- 8KEX chain E against the predicted model P0ABE7: TM-score 0.32, RMSD 3.87 Å
- 8YRG chain R against the predicted model P0ABE7: TM-score 0.33, RMSD 3.89 Å
- 7S8P chain R against the predicted model P0ABE7: TM-score 0.31, RMSD 3.89 Å
- 7S8P chain R against the predicted model P0ABE7: TM-score 0.31, RMSD 3.89 Å
- 8K4S chain E against the predicted model P0ABE7: TM-score 0.28, RMSD 4.42 Å
Elsewhere
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